High Sensitivity of Shotgun Metagenomic Sequencing in Colon Tissue Biopsy by Host DNA Depletion

Medicine, Medical Laboratory Science, Gastroenterology, Life Sciences, Genetics, Microbiology,
host DNA depletion   colon tissue biopsy   shotgun metagenomic sequencing   microbiota   species discovery   disease progression  

High sensitivity of high-throughput metagenomic sequencing in colon tissue biopsies: Eliminating the impact of host DNA Background Evaluating bacterial taxonomic structure through next-generation sequencing without culturing has become a common method for studying the relationship between bacterial imbalance and various diseases. Previous studies h...

Protein Lactylation and Metabolic Regulation of the Zoonotic Parasite Toxoplasma gondii

Medicine, Infectious Diseases, Life Sciences, Biochemistry, Microbiology,
Toxoplasma gondii   lactylation   protein post-translational modification   metabolism   Chip-seq  

A Study on Protein Lactylation and Metabolic Regulation Reveals New Areas of Toxoplasma gondii Biology Background: Toxoplasma gondii is a globally distributed protozoan parasite that infects over 30% of the world’s population. It causes toxoplasmosis, a widespread zoonotic disease. The parasite has a complex life cycle, including sexual and asexual...

Sequence-Based Functional Metagenomics Reveals Novel Natural Diversity of Cu Resistance Gene copa in Environmental Microbiomes

Chemistry, Environmental Chemistry, Life Sciences, Biochemistry, Bioengineering, Microbiology,
Functional Metagenomics   Natural Diversity   Cu Resistance   Evolutionary Trace Analysis   Copper Tolerance  

Sequence-based Functional Metagenomics Reveals New Natural Diversity of Functional COPA Genes in Environmental Microbiomes The natural diversity of functional genes/proteins in environmental microbiomes is an essential component of evolutionary and bioengineering research. To gain a deeper understanding of the diversity of the copper (Cu) resistanc...

A Microbial Metabolite Inhibits the HIF-2α-Ceramide Pathway to Mediate the Beneficial Effects of Time-Restricted Feeding on MASH

Medicine, Hepatobiliary System, Basic Medical Sciences, Life Sciences, Biochemistry, Microbiology,
Microbial Metabolite   Time-Restricted Feeding   HIF-2α   Ceramide   MASH   MASLD   Ruminococcus Torques  

A Microbial Metabolite Mediates the Beneficial Effects of Time-Restricted Feeding on MASH by Inhibiting the HIF-2A-Ceramide Pathway Introduction Background: Metabolic Dysfunction-Associated Steatotic Liver Disease/Metabolic Dysfunction-Associated Steatohepatitis (MASLD/MASH) is a major health problem affecting a quarter of the global population. MA...

Gut Microbial Alterations in Arginine Metabolism Determine Bone Mechanical Adaptation

Medicine, Orthopedics, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Microbiology,
gut microbiota   arginine metabolism   bone adaptation   mechanical loading   osteoporosis  

The Role of Gut Microbial Changes in Lysine Metabolism on Bone Mechanical Adaptation Research Background Osteoporosis, a severe global public health issue, affects over 200 million people, posing significant threats to health and life. Studies have shown that maintaining bone health and preventing osteoporosis are closely linked to mechanical load....

Dysfunctional circadian clock accelerates cancer metastasis by intestinal microbiota triggering accumulation of myeloid-derived suppressor cells

Dysfunctional circadian clock accelerates cancer metastasis by intestinal microbiota triggering accumulation of myeloid-derived suppressor cells

Medicine, Gastroenterology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Microbiology,
circadian rhythm   cancer metastasis   intestinal microbiota   myeloid-derived suppressor cells   tumor microenvironment  

Disruption of Circadian Rhythm Promotes Cancer Metastasis and Myeloid-Derived Suppressor Cell Accumulation Triggered by Intestinal Microbes Academic Background and Research Motivation Cancer metastasis is the leading cause of death for most cancer patients, with colorectal cancer (CRC) drawing significant attention due to its high global incidence ...