Ubiquitin Regulatory X (UBX) Domain-Containing Protein 6 is Essential for Autophagy Induction and Inflammation Control in Macrophages

Medicine, Rheumatology and Immunology, Life Sciences, Cell Biology, Biochemistry, Immunology,
UBXN6   sepsis   inflammation   autophagy   immunosuppression  

Critical Role of UBXN6 in Autophagy Induction and Inflammation Control in Macrophages Background The innate immune system serves as the first line of defense against pathogen invasion and inflammatory responses. Monocytes and macrophages, as key cell types in the innate immune system, play critical roles during infection and inflammation. However, ...

Alternative mRNA Polyadenylation Regulates Macrophage Hyperactivation via the Autophagy Pathway

Medicine, Rheumatology and Immunology, Life Sciences, Cell Biology, Biochemistry, Immunology,
alternative polyadenylation   NUDT21   macrophage   autophagy   inflammation  

NUDT21 Regulates Macrophage Hyperactivation via the Autophagy Pathway Academic Background The inflammatory response is a critical component of the body’s immune defense, facilitating pathogen clearance and tissue repair. However, dysregulation of the inflammatory response can lead to chronic inflammatory diseases such as inflammatory bowel disease ...

Human Dorsal Root Ganglia are Either Preserved or Completely Lost After Deafferentation by Brachial Plexus Injury

Medicine, Anesthesiology, Neurology,
brachial plexus injury   dorsal root ganglia   neuropathic pain   RNA-seq   sensory neurone   transcriptome   inflammation  

Paper Title: Human Dorsal Root Ganglia Are Either Preserved or Completely Lost After Deafferentation by Brachial Plexus Injury Authors: Annemarie Sodmann, Johannes Degenbeck, Annemarie Aue, Magnus Schindehütte, Felicitas Schlott, Panagiota Arampatzi, Thorsten Bischler, Max Schneider, Alexander Brack, Camelia M. Monoranu, Tom Gräfenhan, Michael Bohn...

Multiomic Analysis Identifies Survival Predictors in African American Patients with Acute Myeloid Leukemia

Medicine, Medical Laboratory Science, Hematology, Oncology, Life Sciences, Cell Biology, Immunology, Genetics,
acute myeloid leukemia   African American   gene mutations   inflammation   survival predictors   genomic analysis   multiomic study  

Multi-omics Analysis Reveals Predictors of Survival in African American AML Patients Background and Objectives Acute Myeloid Leukemia (AML) is a hematologic malignancy characterized by clonal expansion of myeloid progenitor cells driven by genomic alterations. Despite advances in genomic profiling, studies focusing on diverse ancestral populations ...

Selective Advantage of Mutant Stem Cells in Human Clonal Hematopoiesis Associated with Attenuated Response to Inflammation and Aging

Medicine, Hematology, Life Sciences, Biochemistry, Immunology, Genetics,
mutant stem cells   clonal hematopoiesis   inflammation   aging   selective advantage   DNMT3A mutation   TET2 mutation  

Selective Advantage of Clonal Hematopoietic Mutant Stem Cells in Aging and Inflammatory Responses Background and Research Motivation Clonal Hematopoiesis (CH) is an aging-related phenomenon in the hematopoietic system, where hematopoietic stem cells (HSCs) acquire specific somatic mutations and undergo expansion, causing a particular mutated cell l...