Phase Ib Trial of Neoadjuvant Oncolytic Virus OrienX010 and Toripalimab in Resectable Acral Melanoma

Neoadjuvant Oncolytic Virus OrienX010 Combined with PD-1 Inhibitor Toripalimab for Resectable Acral Melanoma: Phase Ib Clinical Trial Background Acral melanoma (AM) is a highly aggressive subtype of melanoma with a high incidence in the Chinese population, accounting for approximately 40% of melanoma cases. Despite advances in melanoma treatment, c...

Inhibitory Fcγ Receptor Deletion Enhances CD8 T Cell Stemness Increasing Anti-PD-1 Therapy Responsiveness Against Glioblastoma

Inhibitory Fcγ Receptor Deletion Enhances CD8 T Cell Stemness, Increasing Anti-PD-1 Therapy Responsiveness in Glioblastoma Background and Objectives of the Study Glioblastoma (GBM) is an aggressive central nervous system tumor with poor prognosis, and the median survival of patients is only 14.6 months. Despite the significant efficacy of immune ch...

Cross-Tissue Human Fibroblast Atlas Reveals Myofibroblast Subtypes with Distinct Roles in Immune Modulation

Cross-Organ Human Fibroblast Atlas Reveals Unique Roles of Different Myofibroblast Subtypes in Immune Regulation Research Background and Motivation Fibroblasts play critical roles in maintaining tissue homeostasis, inflammatory responses, fibrosis, and cancer progression. In recent years, the diversity of fibroblasts in the tumor microenvironment (...

Coagulation Factor X Promotes Resistance to Androgen-Deprivation Therapy in Prostate Cancer

Study on the Role of Coagulation Factor X in Anti-androgen Resistance in Prostate Cancer Research Background Prostate cancer (PCa) is the second most common cancer in men worldwide and is one of the leading causes of cancer-related deaths. The occurrence and progression of prostate cancer are highly dependent on the androgen receptor (AR) signaling...

Life History Dynamics of Evolving Tumors: Insights into Task Specialization, Trade-offs, and Tumor Heterogeneity

Cancer Cell International - Review Report Background and Motivation In recent decades, research into cancer evolution has gradually revealed that the evolutionary patterns of cancer cells share many similarities with species evolution. This notion has changed our understanding of tumor evolution and heterogeneity. Cancer is initiated by the mutatio...

Systematic Multiomics Analysis and In Vitro Experiments Suggest ITGA5 as a Promising Therapeutic Target for CCRCC

Systematic Multi-Omics Analysis and In Vitro Experiments Suggest ITGA5 as a Potential Target for Clear Cell Renal Cell Carcinoma (ccRCC) Treatment Research Background and Motivation Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC), accounting for about 75% of all kidney cancer cases. According to the ...

Single-Cell RNA Sequencing and Machine Learning Reveal Relationship Between CD8+ T Cells and Uveal Melanoma Metastasis

Academic Report on “Machine Learning and Single-cell RNA Sequencing Reveal Relationship Between Intratumor CD8+ T Cells and Uveal Melanoma Metastasis” published in Cancer Cell International in 2024 Research Background and Purpose Uveal melanoma (UM) is the most common intraocular malignant tumor in adults. After receiving radiation or surgical trea...

Dysfunctional circadian clock accelerates cancer metastasis by intestinal microbiota triggering accumulation of myeloid-derived suppressor cells

Dysfunctional circadian clock accelerates cancer metastasis by intestinal microbiota triggering accumulation of myeloid-derived suppressor cells

Disruption of Circadian Rhythm Promotes Cancer Metastasis and Myeloid-Derived Suppressor Cell Accumulation Triggered by Intestinal Microbes Academic Background and Research Motivation Cancer metastasis is the leading cause of death for most cancer patients, with colorectal cancer (CRC) drawing significant attention due to its high global incidence ...

BAG6 restricts pancreatic cancer progression by suppressing the release of IL33-presenting extracellular vesicles and the activation of mast cells

Research Report on the Mechanism of BAG6 Restricting Pancreatic Cancer Progression Research Background Pancreatic Ductal Adenocarcinoma (PDAC) has an extremely poor prognosis, with a median survival of only 6 months, urgently requiring new treatment methods. In recent years, studies have found that extracellular vesicles (EVs) released by tumor cel...

High-Dimensional Mapping of Human CEACAM1 Expression on Immune Cells and Association with Melanoma Drug Resistance

The Expression of High-Dimensional Mapping of Human CEACAM1 on Immune Cells and Its Association with Melanoma Drug Resistance Research Background Human Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) is an inhibitory cell surface protein that acts through homophilic and heterophilic ligand binding. The expression of this protein...