Novel Endocytosis Inhibitors Block Entry of HIV-1 Tat into Neural Cells

Chemistry, Medicinal Chemistry, Medicine, Infectious Diseases, Neurology, Life Sciences, Biochemistry, Immunology,
HIV-1 Tat   endocytosis inhibitors   oxidative stress   DNA damage   neural cells  

Novel Endocytosis Inhibitors Block HIV-1 Tat Protein Entry into Neural Cells Academic Background HIV-1 (human immunodeficiency virus type 1) infection not only leads to immune system exhaustion but is also closely associated with HIV-associated neurocognitive disorders (HAND). Although combined antiretroviral therapy (cART) has significantly improv...

Mechanistic Insights into Inactivating Mutations in the Proton-Coupled Folate Transporter (SLC46A1), and Compensatory Mutations that Restore Function

Chemistry, Physical Chemistry, Medicinal Chemistry, Computational Chemistry, Medicine, Life Sciences, Biochemistry, Genetics,
Proton-Coupled Folate Transporter   Inactivating Mutations   Functional Restoration   Molecular Dynamics Simulation   Hereditary Folate Malabsorption  

Research Background and Problem Statement Hereditary Folate Malabsorption (HFM) is a rare autosomal recessive disorder characterized by impaired intestinal absorption of folates and hindered transport across the choroid plexus into cerebrospinal fluid. This disease is caused by inactivating mutations in the gene encoding the Proton-Coupled Folate T...

Homeostasis and Metabolism of Iron and Other Metal Ions in Neurodegenerative Diseases

Chemistry, Medicinal Chemistry, Medicine, Neurology, Life Sciences, Biochemistry,
Neurodegenerative Diseases   Metal Ions   Iron   Manganese   Copper   Zinc   Chelators  

Homeostasis and Metabolism of Iron and Other Metal Ions in Neurodegenerative Diseases Academic Background Neurodegenerative diseases (such as Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, and Huntington’s disease) are characterized by neuronal death and gradual loss of function, leading to the deterioration of cognitive, ...

Machine Learning and Confirmatory Factor Analysis Show that Buprenorphine Alters Motor and Anxiety-like Behaviors in Male, Female, and Obese C57BL/6J Mice

Chemistry, Medicinal Chemistry, Medicine, Psychiatry, Neurology, Life Sciences, Biochemistry,
Buprenorphine   Machine Learning   Confirmatory Factor Analysis   Motor Behavior   Anxiety-like Behavior   C57BL/6J Mice   Obesity  

In recent years, with the global increase in drug abuse, particularly opioids, scientists have become increasingly focused on the neurobehavioral effects of such substances. Among them, buprenorphine, an opioid, is widely used for medication-assisted treatment of opioid addiction. However, beyond its analgesic and addiction treatment effects, bupre...

Hybridization-Based Discovery of Novel Quinazoline-2-Indolinone Derivatives as Potent and Selective PI3Kα Inhibitors

Chemistry, Medicinal Chemistry, Medicine, Pharmacy, Oncology,
molecular hybridization   quinazoline   2-indolinone   PI3Kα inhibitor   non-small cell lung cancer  

Research and Development of a Novel PI3Kα Inhibitor: Molecular Hybridization Technology Leads to a Breakthrough in Lung Cancer Treatment Academic Background Cancer, particularly non-small cell lung cancer (NSCLC), is the second leading cause of death worldwide. Currently, chemotherapy is the primary treatment method, but due to its lack of targetin...