Academic Background Protein self-assembly is a ubiquitous phenomenon in biological systems, performing a wide range of functions from structural support to biochemical regulation. Despite significant progress in protein design in recent years, existing self-assembling protein structures typically rely on strict symmetry, which limits their size and...

Design of Four-Component Protein Nanocages through Programmed Symmetry Breaking Academic Background Protein nanocages are highly symmetric protein assemblies widely used in vaccine development, drug delivery, and nanomaterial design. In nature, viruses often construct complex structures through symmetry breaking, particularly in high triangulation ...

Artificial Dynamic RNA Structure Ensemble-Guided Rational Design of a Universal RNA Aptamer-Based Sensing Tag Academic Background RNA molecules play versatile roles in both natural and synthetic biological systems, with their functions strongly dependent on their dynamic and specific three-dimensional structures. RNA secondary and tertiary structur...

Synthetic Biology in Cancer Immunotherapy: Engineering Bacteria to Inhibit IDO Activity and Reprogram CD8+ T Cell Responses Academic Background In recent years, significant progress has been made in cancer immunotherapy, particularly through the activation of T cells to combat tumors. However, metabolic adaptations in the tumor microenvironment (TM...

Summary of FingerNeRF-Based 3D Finger Biometrics Research Report Background and Research Significance With the advancement of biometric technologies, three-dimensional (3D) biometrics have become a promising research direction due to their higher accuracy, robust anti-spoofing capabilities, and resistance to variations in capture angles. Among thes...