Adaptation of Control Policy to Task Demands in Motor Control: During Both Motor Execution and Motor Planning

Adjustment of Motor Control Policies and Adaptation to Task Demands Academic Background Motor control is a core research area in neuroscience and movement science, particularly in understanding how humans plan and execute complex movements. Motor planning involves multiple processes, including target selection, application of task demands, action s...

Improving Localization and Measurements of M-Waves Using High-Density Surface Electromyography

Improving Localization and Measurement of M-Waves Using High-Density Surface Electromyography Academic Background Surface electromyography (sEMG) is an important tool for studying muscle function and controlling prosthetics. However, its effectiveness is often limited by cross talk from nearby muscles, especially in densely packed areas like the fo...

Development and Application of an Automated In Vitro Model for Hydrocephalus Research

Application of Automated In Vitro Models in Hydrocephalus Research Background Introduction Hydrocephalus is a neurological condition caused by the accumulation of cerebrospinal fluid (CSF) in the brain’s ventricles. If left untreated, it can lead to severe complications and permanent brain damage. It is estimated that 1 in every 500 newborns is bor...

Numerical Study of the Effects of Minor Structures and Mean Velocity Fields in the Cerebrospinal Fluid Flow

Study on Cerebrospinal Fluid Flow Dynamics and Its Application in Drug Delivery Background Introduction Cerebrospinal fluid (CSF) plays a crucial role in the human spinal canal, responsible for transporting dissolved nutrients and waste products. Due to its pulsatile nature, CSF flow is influenced by cardiac and respiratory cycles. In recent years,...

Genome-aware annotation of CRISPR guides validates targets in variant cell lines and enhances discovery in screens

Genomic Medicine and Re-annotation of CRISPR Guides: Application and Validation of the EXORCISE Algorithm Academic Background The advent of CRISPR-Cas9 technology has revolutionized genetic screening, particularly in studying gene essentiality and chemo-genetic interactions. By designing guide RNAs (gRNAs) that target specific genes, the CRISPR-Cas...