Mechanical Ventilation Guided by Driving Pressure Optimizes Local Pulmonary Biomechanics in an Ovine Model

Engineering, Mechanical Engineering, Medicine, Respiratory System, Anesthesiology, Medical Imaging, Life Sciences, Bioengineering,
Mechanical ventilation   Driving pressure   Pulmonary biomechanics   Acute respiratory distress syndrome   Whole-lung image segmentation  

Optimization of Respiratory Pressure Under Mechanical Ventilation Guidance - A Study on Improving Local Lung Biomechanics Mechanical ventilation is commonly used in clinical practice to treat acute respiratory distress syndrome (ARDS) and prevent pulmonary complications after general anesthesia. However, mechanical ventilation can cause harmful str...

A Self-Amplifying RNA Vaccine Prevents Enterovirus D68 Infection and Disease in Preclinical Models

Medicine, Infectious Diseases, Respiratory System, Life Sciences, Bioengineering, Immunology, Microbiology,
RNA vaccine   Enterovirus D68   nonenveloped virus   antibody responses   vaccine platform   antigenic diversity   preventive vaccine  

A Study on Self-Amplifying RNA Vaccine for Prevention of Enterovirus D68 Infection and Disease in Clinical Models 1. Background In recent years, rapid response to emerging infectious diseases and vaccine development have received much attention. Particularly, the emergence of the novel coronavirus (SARS-CoV-2) has led to rapid advancement in RNA va...

Engineered Exosomes with a Photoinducible Protein Delivery System Enable CRISPR-Cas–Based Epigenome Editing in Alzheimer’s Disease

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
engineered exosomes   photoinducible protein   Alzheimer’s disease   CRISPR-Cas   epigenome editing   delivery system   memory improvement  

CRISPR-Cas-Based Epigenome Editing in Alzheimer’s Disease: Engineered Exosomes with a Photoinducible Protein Delivery System Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by progressive decline in cognitive function and memory, with currently limited treatment options. Genome editing technologies, such as ...

Transcriptome Dynamics and Cell Dialogs Between Oocytes and Granulosa Cells in Mouse Follicle Development

Medicine, Obstetrics and Gynecology, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
oocyte   granulosa cell   transcriptome   folliculogenesis   cell dialog  

Transcriptome Dynamics and Cell Dialogue Between Oocytes and Granulosa Cells During Mouse Follicle Development Overview Follicle development and maturation is a complex, multi-stage process. During this process, dynamic gene expression in oocytes and surrounding somatic cells, as well as the dialogue between them, play crucial roles. This study rev...

Benchmarking Algorithms for Gene Set Scoring of Single-Cell ATAC-Seq Data

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
single-cell ATAC-Seq   gene set scoring   pathway analysis   single-cell RNA-Seq   benchmark  

Benchmarking Gene Set Scoring Tools for Single-Cell ATAC-seq Data Authors: Xi Wang, Qiwei Lian, Haoyu Dong, Shuo Xu, Yaru Su, Xiaohui Wu Affiliations: Pasteurien College (Soochow University Medical College), Department of Automation, Xiamen University, School of Mathematics and Computer Science, Fuzhou University Corresponding Author: xhwu@suda.edu...