Overcoming the Preferred-Orientation Problem in Cryo-EM with Self-Supervised Deep Learning

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Biochemistry, Biophysics,
cryo-EM   preferred-orientation problem   self-supervised learning   deep learning   3D reconstruction   molecular structure   biological macromolecules  

Overcoming the Preferred-Orientation Problem in Single-Particle Cryo-EM: An Innovative Solution through Deep Learning Background Introduction In recent years, single-particle cryogenic electron microscopy (Single-Particle Cryo-EM) has become a core technique in structural biology due to its ability to resolve the atomic-resolution structures of bio...

Direct Observation of Small Molecule Activator Binding to Single PR65 Protein

Chemistry, Medicinal Chemistry, Medicine, Life Sciences, Biochemistry, Biophysics,
Protein Phosphatase 2A   Small Molecule Activator   Nanoaperture Optical Tweezers   Binding Kinetics   Molecular Dynamics Simulation  

Single-Molecule Optical Tweezer Technique Reveals the Binding Mechanism of a Small Molecule Activator and PR65 Protein Academic Background Protein phosphatase 2A (PP2A) is a crucial enzyme in regulating cellular signaling. Its dysfunction is closely associated with various cancers and chronic diseases, such as Alzheimer’s disease and chronic obstru...

Resolving Native GABAA Receptor Structures from the Human Brain

Medicine, Neurology, Life Sciences, Biochemistry, Biophysics,
GABAA receptor   structural analysis   epilepsy   cryo-electron microscopy   drug binding   neurotransmitter   human brain  

Resolving Native GABAA Receptor Structures from the Human Brain: A Breakthrough Study Academic Background GABAA receptors (γ-aminobutyric acid type A receptors) are among the most important inhibitory neurotransmitter receptors in the brain, responsible for regulating fast inhibitory signaling in neurons. These receptors are not only key drug targe...

Oscillatory Transcranial Electrical Stimulation and the Amplitude-Modulated Frequency Dictate the Quantitative Features of Phosphenes

Medicine, Neurology, Ophthalmology, Life Sciences, Biophysics,
transcranial electrical stimulation   phosphene   amplitude modulation frequency   oscillatory current   visual perception  

Oscillatory Transcranial Electrical Stimulation and the Quantitative Features of Phosphene Perception Background Introduction Phosphenes refer to the phenomenon of perceiving light points without any external visual stimuli. This phenomenon holds significant importance in visual neuroscience and consciousness studies, as it helps us understand how ...

Circulating Extracellular Vesicles as Promising Biomarkers for Precision Diagnostics: A Perspective on Lung Cancer

Medicine, Respiratory System, Oncology, Life Sciences, Biochemistry, Bioengineering, Immunology, Genetics, Biophysics,
extracellular vesicles   lung cancer   liquid biopsy   biosensors   early detection   precision medicine   nanotechnology  

Exosomes as Biomarkers for Precision Diagnosis of Lung Cancer Academic Background Lung cancer is one of the leading causes of cancer-related deaths worldwide, with early diagnosis and precision treatment of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) remaining significant challenges. Although traditional tissue biopsy is co...