Pathogenic Variants in the Polycystin Pore Helix Cause Distinct Forms of Channel Dysfunction

Medicine, Basic Medical Sciences, Nephrology, Life Sciences, Cell Biology, Biochemistry, Genetics, Biophysics,
autosomal dominant polycystic kidney disease   polycystin   PKD2   ion channels   cryo-EM   channel dysfunction   protein assembly  

Molecular Mechanism Analysis of ADPKD Pathogenic Variants in Ion Channels – In-depth Interpretation of PNAS 2025 Latest Original Research I. Academic Research Background and Scientific Significance Autosomal Dominant Polycystic Kidney Disease (ADPKD) is one of the most common monogenic disorders worldwide, affecting millions of individuals. The pat...

Intermediate Light Adaptation Induces Oscillatory Phototaxis Switching and Pattern Formation in Chlamydomonas

Physics, Fluid Physics, Life Sciences, Cell Biology, Biophysics, Botany, Microbiology,
Chlamydomonas   phototaxis   light adaptation   flagella beats   microswimmers   behavioral switching   pattern formation  

New Discovery of Green Microswimmer: Oscillatory Phototaxis and Pattern Formation Induced by Light Adaptation — Review of “intermediate light adaptation induces oscillatory phototaxis switching and pattern formation in chlamydomonas” 1. Research and Academic Background Light, as a core environmental signal for living organisms, drives diverse behav...

The Dependence of Amino Acid Backbone Conformation on the Translated Synonymous Codon Is Not Statistically Significant

Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics, Biophysics,
synonymous codon   protein structure   dihedral angle   statistical analysis   protein folding   translation regulation  

Re-evaluating the Influence of Synonymous Codons on Protein Backbone Conformation — A Dialectic Under Rigorous Statistical Testing in Structural Biology 1. Academic Background and Research Motivation In the fields of molecular biology and structural biology, the relationship between codons and protein structure has long been a focal point of resear...

Mechanistic Analysis of Channel Dysfunction Caused by Diverse Pathogenic Polycystin Pore Helix Variants

Medicine, Basic Medical Sciences, Nephrology, Life Sciences, Cell Biology, Biochemistry, Genetics, Biophysics,
autosomal dominant polycystic kidney disease   polycystin   channelopathy   ion channel   primary cilia   structure   drug development  

I. Research Background and Scientific Significance Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common monogenic hereditary kidney disease that affects millions of people worldwide. ADPKD is primarily caused by mutations in the renal polycystin family (especially the PKD1 and PKD2 genes), which encode channel subunits pivotal for ion c...

Local and Distal Dynamic Changes Caused by the L205R Cushing’s Syndrome Mutant in PRKACA

Medicine, Endocrinology, Life Sciences, Cell Biology, Biochemistry, Biophysics,
L205R mutation   Cushing’s syndrome   protein kinase A   molecular dynamics simulation   local spatial pattern   protein residue networks  

New Insights into the Molecular Dynamics and Allosteric Network Regulation Mechanisms of the Common Cushing’s Syndrome Mutation L205R in Protein Kinase A: Interpreting the Latest Original Research from PNAS I. Research Background and Scientific Questions Protein kinase A (PKA) is a key intracellular signal transduction molecule that regulates a var...