Microglia and Macrophages in Glioblastoma: Landscapes and Treatment Directions

Medicine, Neurology, Neurosurgery, Oncology, Life Sciences, Immunology,
glioblastoma   microglia   macrophages   tumor microenvironment   immunotherapy   single-cell sequencing   tumor-associated macrophages  

Microglia and Macrophages in Glioblastoma Academic Background Glioblastoma (GBM) is the most common primary malignant tumor of the central nervous system, characterized by high invasiveness and lethality. Despite standard treatments such as surgery, chemotherapy, and radiotherapy, the survival rate of patients remains extremely limited, with a medi...

CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy

Medicine, Infectious Diseases, Neurology, Life Sciences, Cell Biology, Immunology,
CD137L   microglia   inflammation   anxiety   cognition   TKS-1  

Background Introduction Sepsis is a life-threatening multiple organ dysfunction syndrome caused by uncontrolled infection in the host, and is one of the leading causes of death in intensive care units. It is reported that there are approximately 189 adult sepsis hospitalization cases per 100,000 person-years, with a mortality rate of 26.7%. Sepsis-...

Triggering Receptor Expressed on Myeloid Cells 2 Alleviated Sevoflurane-Induced Developmental Neurotoxicity via Microglial Pruning of Dendritic Spines in the CA1 Region of the Hippocampus

Medicine, Pediatrics, Anesthesiology, Neurology, Life Sciences, Cell Biology, Immunology,
CA1 neurons   dendritic spines   developmental neurotoxicity   microglia   sevoflurane   TREM2  

TREM2 Expression on Mouse Astrocytes Prevents Sevoflurane-Induced Developmental Neurotoxicity Through Microglial Pruning of Dendritic Spines in Hippocampal CA1 Region Research Background and Significance Sevoflurane is one of the most widely used anesthetics in pediatric anesthesia. Early multiple exposures to sevoflurane can lead to developmental ...

Amorfrutin B Compromises Hypoxia/Ischemia-Induced Activation of Human Microglia in a PPARγ-Dependent Manner: Effects on Inflammation, Proliferation Potential, and Mitochondrial Status

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
microglia   inflammation   selective PPARγ modulator   perinatal asphyxia   stroke  

Research on the Effects of Amorfrutin B on Human Microglia under Hypoxia/Ischemia Conditions: Anti-inflammatory Action, Proliferation Potential, and Mitochondrial State Based on the PPARγ Pathway Research Background Hypoxia/ischemia is a major cause of brain injury in both neonatal and adult populations. Perinatal asphyxia and ischemic stroke are l...

Repetitive Administration of Low-Dose Lipopolysaccharide Improves Repeated Social Defeat Stress-Induced Behavioral Abnormalities and Aberrant Immune Response

Medicine, Psychiatry, Neurology, Clinical Psychology, Life Sciences, Biochemistry, Immunology,
lipopolysaccharide   social defeat stress   immune response   behavioral abnormalities   microglia  

Repeated Low-Dose Lipopolysaccharide Pretreatment Improves Behavioral Abnormalities and Aberrant Immune Responses Induced by Repeated Social Defeat Stress Background Stress significantly impacts human health, with chronic stress particularly inducing various physiological and psychological disorders. The hypothalamic-pituitary-adrenal (HPA) axis is...

The Sirtuin 5 Inhibitor MC3482 Ameliorates Microglia-Induced Neuroinflammation Following Ischaemic Stroke by Upregulating the Succinylation Level of Annexin-A1

Medicine, Neurology, Neurosurgery, Life Sciences, Cell Biology, Immunology,
ischaemic stroke   neuroinflammation   microglia   SIRT5   Annexin-A1   MC3482   desuccinylation  

The Sirtuin 5 Inhibitor MC3482 Ameliorates Microglia-Induced Neuroinflammation following Ischaemic Stroke by Upregulating the Succinylation Level of Annexin-A1 Background Ischaemic stroke is the most common type of stroke and a leading cause of death and disability worldwide. Its pathogenesis is complex, involving processes such as oxidative stress...