End-to-End Prediction of Knee Osteoarthritis Progression with Multimodal Transformers

End-to-end Prediction of Knee Osteoarthritis Progression Using Multimodal Transformers I. Academic Background Knee osteoarthritis (KOA) is a chronic musculoskeletal disease that affects hundreds of millions of people worldwide. Due to gradual degeneration of articular cartilage and bone, KOA typically leads to chronic pain, joint stiffness, and fun...

Exosomes Derived from Exercise-Trained Mice Bone Marrow Mesenchymal Stem Cells Improve Wound Healing by Inhibiting Macrophage M1 Polarization

I. Academic Background and Research Significance Wound healing is a highly complex physiological process that plays a crucial role in tissue regeneration, repair, and immune regulation. However, poor healing of chronic wounds is clinically widespread, severely impacting patients’ quality of life and increasing medical and socioeconomic burdens. The...

Tissue Engineered Scaffolds Combined with Exercise in the Treatment of Volumetric Muscle Loss in Rat Model

Academic Background Volumetric Muscle Loss (VML) is a severe muscle injury typically caused by trauma, ischemia, or tumor excision. VML leads to irreversible loss of muscle fibers, resulting in fibrosis, deformity, and long-term dysfunction. Unlike ordinary muscle injuries, VML has very limited regenerative capacity because the extent of damage exc...

A Polyphenol–Metal Network of Propyl Gallate Gallium/Hafnium Oxide on Polyimide Fibers for Facilitating Ligament–Bone Healing

Study on Surface Modification of Polyimide Fibers to Promote Ligament-Bone Healing Academic Background Anterior Cruciate Ligament (ACL) injury is one of the most common sports injuries worldwide, with approximately 1 in 1,250 people requiring ACL reconstruction surgery each year. Currently, the main methods for ACL reconstruction include autografts...

Ketones in Cellular Physiology: Metabolic, Signaling, and Therapeutic Advances

Research Report: The Role of Ketones in Cellular Physiology: Metabolic, Signaling, and Therapeutic Advances Academic Background For a long time, carbohydrate (CHO) intake has been considered a key factor in enhancing athletic performance during endurance exercise. The traditional view holds that a high-carbohydrate low-fat diet (HCLF) can increase ...