Flexible Control of Sequence Working Memory in the Macaque Frontal Cortex

Research Background In our daily lives, Sequence Working Memory (SWM) is crucial; for example, when filling in a birth date, the year, month, and day need to be recalled and arranged in a specific order. However, how the brain controls information in sequential memory and flexibly orders information under different task demands remains an unsolved ...

Molecular and Circuit Determinants in the Globus Pallidus Mediating Control of Cocaine-Induced Behavioral Plasticity

Scientific News Report: The Molecular and Neural Circuit Mechanisms in the Globus Pallidus for Controlling Cocaine-Induced Behavioral Plasticity In the field of the neurobiology of drug abuse, this paper provides a new perspective for exploring cocaine-induced behavioral plasticity and neural circuit regulation. The research team centered on the Gl...

Negative Feedback Control of Hypothalamic Feeding Circuits by the Taste of Food

I. Research Background The taste of food has a significant impact on the feeding motivation of animals. Previous research has shown that taste, as a positive feedback signal, can enhance the feeding motivation of animals. However, in recent years, studies on whether taste also plays a role in suppressing feeding and helping achieve negative feedbac...

Transformation of Neural Coding for Vibrotactile Stimuli Along the Ascending Somatosensory Pathway

Research Background The neural transduction mechanisms of tactile vibration coding have been a hot topic in neuroscience research. In daily life, we acquire information about the external environment through the perception of vibrations, such as phone vibration alerts or car proximity warnings. In mammals, high-frequency vibration perception is mai...

Structural Basis of Psychedelic LSD Recognition at Dopamine D1 Receptor

Structural Basis of LSD Recognition in Dopamine D1 Receptors Research Background and Problem Statement LSD (lysergic acid diethylamide) is a well-known hallucinogen that primarily exerts profound cognitive and perceptual effects by acting on various neurotransmitter receptors, including serotonin (5-HT) receptors and dopamine receptors. The 5-HT2A ...