Amino Acid is a Major Carbon Source for Hepatic Lipogenesis

Research Report on the Relationship Between High Protein Diet and Liver Fat Synthesis Background and Significance Globally, the prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is gradually increasing, becoming a common issue among people with obesity and insulin resistance. The pathological development of this disease...

Hexokinase 2 Senses Fructose in Tumor-Associated Macrophages to Promote Colorectal Cancer Growth

Hexokinase 2 Senses Fructose in Tumor-Associated Macrophages to Promote Colorectal Cancer Growth

Fructose Promotes Colorectal Cancer Growth by Modulating Tumor-Associated Macrophage Polarization Introduction In recent years, fructose intake has dramatically increased worldwide and is closely associated with obesity and metabolic syndrome, both of which are recognized risk factors for cancer development. Although previous studies have shown tha...

Multi-Omic Mapping of Human Pancreatic Islet Endoplasmic Reticulum and Cytokine Stress Responses Provides Genetic Insights into Type 2 Diabetes

Background and Research Motivation Globally, Type 2 Diabetes (T2D) is a common metabolic disease characterized by the combined effects of genetic and environmental factors leading to dysfunction and/or cell death of pancreatic β-cells, resulting in insufficient insulin secretion. Based on findings from Genome-Wide Association Studies (GWAS), over 6...

GPR56-mediated sensing of the steroid hormone 17α-hydroxypregnenolone protects against ferroptosis-induced liver injury

The Role of Protein-Coupled Receptor GPR56 and Its Protective Mechanism in Ferroptosis-Induced Liver Injury In recent years, ferroptosis has emerged as a new form of programmed cell death, becoming a hot topic in scientific research. It is characterized by cell death due to phospholipid peroxidation and is significantly different from traditional a...

Dietary Timing-Induced Gut Microbiota Diurnal Oscillations Modulate Inflammatory Rhythms in Rheumatoid Arthritis

Influence of Dietary Timing on Circadian Rhythms of Gut Microbiota and Rheumatoid Arthritis Inflammation Background Introduction Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by systemic inflammation and progressive joint destruction, severely affecting the quality of life of patients. The inflammation and symptoms of RA p...