Astaxanthin Rescues Memory Impairments in Rats with Vascular Dementia by Protecting Against Neuronal Death in the Hippocampus

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
vascular dementia   astaxanthin   Alzheimer’s disease   neurodegenerative diseases   neuronal apoptosis  

Astaxanthin Protects Hippocampal Neurons Against Memory Impairment Caused by Vascular Dementia in Rats Background Introduction Vascular Dementia (VAD) is a progressive cognitive disorder caused by cerebrovascular disease leading to cognitive decline. Current research shows that chronic cerebral hypoperfusion (CCH) and insufficient blood supply are ...

Evaluation of Neuroprotective Effect of Gut Microbe in Parkinson's Disease: An In Silico and In Vivo Approach

Medicine, Neurology, Life Sciences, Biochemistry, Immunology, Microbiology,
α-synuclein   gut microbes   metabolites   protein-protein interaction   therapeutic agent   parkinsonian mice model  

Study on the Protective Effects of Medicinal Microorganisms on Parkinson’s Disease Background Introduction Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterized by the death of dopaminergic neurons in the substantia nigra region of the brain. The aggregation of α-synuclein is a crucial factor in the pathogenesis of Park...

Physical Exercise Inhibits Cognitive Impairment and Memory Loss in Aged Mice, and Enhances Pre- and Post-Synaptic Proteins in the Hippocampus of Young and Aged Mice

Medicine, Geriatrics, Neurology, Sports Medicine, Life Sciences, Cell Biology, Biochemistry,
swimming   physical activity   dementia   synapses   brain  

A scientific paper authored by Ricardo Augusto Leoni de Sousa and his research team was published in Volume 26, Issue 31 of the journal “Neuromolecular Medicine” in 2024. The paper is titled “Physical exercise inhibits cognitive impairment and memory loss in aged mice, and enhances pre- and post-synaptic proteins in the hippocampus of young and age...

CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy

Medicine, Infectious Diseases, Neurology, Life Sciences, Cell Biology, Immunology,
CD137L   microglia   inflammation   anxiety   cognition   TKS-1  

Background Introduction Sepsis is a life-threatening multiple organ dysfunction syndrome caused by uncontrolled infection in the host, and is one of the leading causes of death in intensive care units. It is reported that there are approximately 189 adult sepsis hospitalization cases per 100,000 person-years, with a mortality rate of 26.7%. Sepsis-...

Genetic Variations and Altered Blood mRNA Level of Circadian Genes and BDNF as Risk Factors of Post-Stroke Cognitive Impairment among Eastern Indians

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
Post-stroke cognitive impairment   Circadian clock   BDNF   Polymorphism   Risk factors  

Gene Variants and Altered Blood mRNA Levels as Risk Factors for Post-Stroke Cognitive Impairment in Indians Research Background Cognitive impairment is a common clinical outcome after stroke, occurring in about 30% of stroke survivors. Research has shown that Brain-Derived Neurotrophic Factor (BDNF) plays an important role in this process, and BDNF...