Comprehensive Genomic Analysis of Patients with Non–Small-Cell Lung Cancer Using Blood-Based Circulating Tumor DNA Assay: Findings from the BFAST Database of a Single Center in Taiwan

Medicine, Medical Laboratory Science, Hematology, Oncology, Life Sciences, Immunology, Genetics,
Non-Small-Cell Lung Cancer   Blood Test   Circulating Tumor DNA   Genomic Analysis   BFAST   Actionable Mutations  

Latest Research in Lung Cancer Genomics: Analysis of Circulating Tumor DNA Detection in Non-Small Cell Lung Cancer Background and Motivation In recent years, the treatment of non-small cell lung cancer (NSCLC) has seen significant changes due to the success of targeted therapies. The National Comprehensive Cancer Network guidelines recommend extens...

Pan-Cancer Interrogation of MUTYH Variants Reveals Biallelic Inactivation and Defective Base Excision Repair Across a Spectrum of Solid Tumors

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Biochemistry, Immunology, Genetics,
pan-cancer   MUTYH variants   biallelic inactivation   base excision repair   tumors  

Cross-Cancer Study Reveals Biallelic Inactivation of MUTYH and Base Excision Repair Defects in Different Types of Solid Tumors Research Background In daily life, cells are often exposed to endogenous and exogenous oxidative stress, originating from by-products of cellular respiration and various external compounds. MUTYH is a key component of the b...

Hereditary Cancer Screening and Outcomes at an Urban Safety-Net Hospital

Medicine, Medical Laboratory Science, Oncology, Life Sciences, Genetics,
Hereditary Cancer Syndromes   Genetic Testing   Cancer Risk   Urban Hospital   Ethnic Minorities   Disparities   Cancer Care  

Screening and Outcomes of Hereditary Cancer Syndromes: A Study at an Urban Safety Net Hospital Study Background Patients with Hereditary Cancer Syndromes (HCS) have a higher lifetime risk of developing cancer. Historically, underserved populations have lower rates of genetic evaluation. Hence, researchers aim to understand the demographic factors i...

Genomic Profiling of Rare Undifferentiated Sarcomatoid Subtypes of Pancreatic Carcinomas: In Search of Therapeutic Targets

Medicine, Medical Laboratory Science, Oncology, Life Sciences, Biochemistry, Immunology,
Undifferentiated Sarcomatoid Carcinoma   Pancreatic Cancer   Genomic Profiling   Therapeutic Targets   Immune Checkpoint Inhibitors  

Genomic Characteristics of a Rare Pancreatic Cancer Undifferentiated Sarcomatoid Carcinoma Subtype Academic Background Pancreatic Ductal Adenocarcinoma (PDAC) is one of the deadliest cancers, characterized by early invasion and metastasis. Undifferentiated Sarcomatoid Carcinoma (USC) is a particularly aggressive but rare subtype of PDAC, accounting...

Analysis of Breast Cancer Brain Metastases Reveals an Enrichment of Cyclin-Dependent Kinase 12 Structural Rearrangements in Human Epidermal Growth Factor Receptor 2–Positive Disease

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
breast cancer   brain metastasis   structural rearrangement   cyclin-dependent kinase 12   HER2   genomics   targeted therapy  

Research Report on CDK12 Structural Rearrangements in Brain Metastases of Breast Cancer Background and Purpose Breast Cancer (BC) is the second most common solid tumor involving the Central Nervous System (CNS). Brain Metastases from Breast Cancer (BCBMs) are becoming increasingly common among patients with metastatic breast cancer. Patients with a...