Tumor-Associated NK Cells Drive MDSC-Mediated Tumor Immune Tolerance Through the IL-6/STAT3 Axis

Medicine, Oncology, Life Sciences, Immunology,
NK cells   MDSC   tumor immune escape   IL-6   STAT3   antigen presentation   immune checkpoint inhibition  

Tumor-Associated NK Cells Drive MDSC-Mediated Tumor Immune Tolerance via the IL-6/STAT3 Axis — Research by Neo et al. In recent years, researchers have delved deeply into the mechanisms of tumor immune escape to improve the success rate of cancer immunotherapy. The accumulation of CD8 T cells in the tumor microenvironment is a critical determinant ...

Neuronal population activity in the olivocerebellum encodes the frequency of essential tremor in mice and patients

Medicine, Basic Medical Sciences, Neurology, Neurosurgery, Life Sciences, Biophysics,
essential tremor   cerebellum   olivary body   neuronal population activity   EEG   frequency encoding   deep brain stimulation  

Encoding of Cerebellar-Olivary Neuronal Ensemble Activity for Tremor Frequency in Mice and Patients with Essential Tremor Research Background Essential Tremor (ET) is a common movement disorder characterized primarily by action tremor, affecting about 20% of the elderly population. The frequency and intensity of tremor are core features of ET. Howe...

Attenuation of Fibroblast Activation and Fibrosis by Adropin in Systemic Sclerosis

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Life Sciences, Biochemistry,
systemic sclerosis   fibroblast   fibrosis   Adropin   TGFB   fibrosis therapy   RNA sequencing  

Reducing Fibroblast Activation and Fibrosis in Systemic Sclerosis through Adropin Fibrotic diseases of the skin and other organs have become significant socioeconomic challenges in modern society, and current treatment options are limited. This background for this study seeks to address the problem of fibrosis in Systemic Sclerosis (SSc), with the ...

Gain-of-Function Mutations of TRPV4 Acting in Endothelial Cells Drive Blood-CNS Barrier Breakdown and Motor Neuron Degeneration in Mice

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry,
TRPV4   Blood-CNS Barrier   Endothelial Cells   Motor Neuron Degeneration   Mouse Model   Mutations   Therapeutic Strategy  

This article is written by Jeremy M. Sullivan et al. and published in the journal “Science Translational Medicine” on May 22, 2024, titled “Gain-of-function TRPV4 Mutations in Endothelial Cells Disrupt the Blood-Spinal Cord Barrier and Cause Motor Neuron Degeneration in Mice.” Academic Background The research background of this article revolves aro...

Reactivating PTEN to Impair Glioma Stem Cells by Inhibiting Cytosolic Iron-Sulfur Assembly

Medicine, Neurosurgery, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
PTEN   Glioma Stem Cells   Iron-Sulfur Clusters   Drug Combination   Desuccination  

Using the Suppression of Cytoplasmic Iron-Sulfur Cluster Assembly to Restore PTEN and Inhibit Glioma Stem Cells Background Glioblastoma (GBM) is one of the most lethal primary brain tumors. Glioma stem cells (GSCs) not only initiate and sustain the malignant phenotype but also enhance treatment resistance. Although PTEN frequently mutates in gliobl...