Cataract-Prone Variants of γD-Crystallin Populate a Conformation with a Partially Unfolded N-Terminal Domain under Native Conditions

Life Sciences, Biochemistry,
γD-crystallin   cataract   protein folding   hydrogen–deuterium exchange mass spectrometry   structural intermediate   aggregation   eye lens  

Study on Partially Unfolded Intermediate of γD-Crystallin Variants under Native Conditions Academic Background Human γD-crystallin is a structural protein in the eye lens, crucial for maintaining its transparency and stability. It must remain folded throughout an individual’s lifetime to avoid aggregation and protein deposition, thus preventing cat...

Human MAIT Cell Response Profiles Biased Toward IL-17 or IL-10 Are Distinct Effector States Directed by the Cytokine Milieu

Life Sciences, Cell Biology, Immunology,
MAIT cells   cytokines   IL-10   IL-17   immune function  

Functional Plasticity of Human MAIT Cells and Their Role in Immune Regulation Academic Background Mucosal-Associated Invariant T cells (MAIT cells) are a type of unconventional T lymphocyte found abundantly in healthy humans, especially in mucosal tissues. MAIT cells exhibit innate-like characteristics, rapidly recognizing antigens derived from mic...

Spatial Patterning Analysis of Cellular Ensembles (SPACE) Detects Complex Spatial Organization at the Cell and Tissue Levels

Life Sciences, Cell Biology, Bioengineering,
Spatial Biology   Spatial Statistics   Information Theory   Imaging   Microscopy  

Spatial Patterning Analysis of Cellular Ensembles (SPACE): Revealing Complex Spatial Patterns in Biological Tissues Academic Background The function of biological tissues depends on the interactions of cells, molecules, and structures in three-dimensional space. Understanding these spatial organization patterns can provide new insights into patholo...

Fixational Eye Movements as Active Sensation for High Visual Acuity

Medicine, Neurology, Ophthalmology, Life Sciences, Biophysics,
fixational eye movements   visual acuity   retinal coding   Bayesian inference   adaptive optics  

Fixational Eye Movements as Active Sensation for High Visual Acuity Academic Background Human visual perception is a complex process, especially when we attempt to maintain stable gaze. Even then, the eyes still produce small involuntary movements known as fixational eye movements (FEM). These FEM typically include drifts and microsaccades. Previou...

Intracranial Substrates of Meditation-Induced Neuromodulation in the Amygdala and Hippocampus

Medicine, Neurology, Life Sciences,
meditation   amygdala   hippocampus   neuromodulation   electrophysiology  

Study on the Neuroregulatory Effects of Meditation: A Case Study of Loving-Kindness Meditation Academic Background Meditation, as a mental training technique, has long been believed to regulate emotions and enhance mental health. Specifically, Loving-Kindness Meditation (LKM), which focuses on cultivating positive emotions towards oneself and other...