Increased Robustness and Adaptation of the Crab Pyloric Rhythm to Simultaneous Temperature and Elevated Extracellular Potassium Academic Background In nature, animals often face multiple simultaneous environmental perturbations, which may include temperature fluctuations, pH variations, salinity changes, and alterations in extracellular potassium c...

Micropipette-Image Calibration Method Based on Micromanipulation System for Somatic Cell Microinjection Research Background Microinjection is a technique that employs a fine micropipette to inject a precise amount of genetic material, drugs, or other exogenous substances directly into cells or tissues. This technology plays a pivotal role in biomed...

Adiporon Ameliorates the Progression of Heart Failure with Preserved Ejection Fraction (HFpEF) by Reducing Lipid Accumulation and Fibrosis Research Background Heart failure with preserved ejection fraction (HFpEF) is the most common type of heart failure, often coexisting with metabolic disorders such as obesity, diabetes, and hypertension. Althoug...

Moscatilin Inhibits Vascular Calcification by Activating IL13RA2-dependent Inhibition of STAT3 and Attenuating the Wnt3/β-catenin Signaling Pathway Background Vascular calcification is a pathological process involving the deposition of hydroxyapatite in the vessel wall, often associated with atherosclerotic cardiovascular disease and chronic kidney...

DNA Hypomethylation-Mediated Upregulation of GADD45B Facilitates Airway Inflammation and Epithelial Cell Senescence in COPD Academic Background Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous disease characterized by chronic airway inflammation and irreversible airflow limitation, and it is one of the leading causes of death worldwi...