Prognostic Value of Serial Postoperative Circulating Tumor DNA Assessment During Long-Term Follow-Up in Patients with Breast Cancer

Prognostic Value of Serial Postoperative Circulating Tumor DNA Assessment During Long-Term Follow-Up in Patients with Breast Cancer

Medicine, Medical Laboratory Science, Oncology, Life Sciences, Immunology,
Breast Cancer   Circulating Tumor DNA   Long-Term Follow-Up   Prognosis   Personalized Medicine  

Scientific Research Report Background Introduction Breast cancer is the most commonly diagnosed cancer worldwide among both men and women, and it is the leading cause of cancer-related deaths in women. The standard treatment for early-stage breast cancer usually involves surgery and (neo)adjuvant chemotherapy and/or endocrine therapy, aiming to eli...

Comprehensive Genomic Analysis of Patients with Non–Small-Cell Lung Cancer Using Blood-Based Circulating Tumor DNA Assay: Findings from the BFAST Database of a Single Center in Taiwan

Medicine, Medical Laboratory Science, Hematology, Oncology, Life Sciences, Immunology, Genetics,
Non-Small-Cell Lung Cancer   Blood Test   Circulating Tumor DNA   Genomic Analysis   BFAST   Actionable Mutations  

Latest Research in Lung Cancer Genomics: Analysis of Circulating Tumor DNA Detection in Non-Small Cell Lung Cancer Background and Motivation In recent years, the treatment of non-small cell lung cancer (NSCLC) has seen significant changes due to the success of targeted therapies. The National Comprehensive Cancer Network guidelines recommend extens...

Pan-Cancer Interrogation of MUTYH Variants Reveals Biallelic Inactivation and Defective Base Excision Repair Across a Spectrum of Solid Tumors

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Biochemistry, Immunology, Genetics,
pan-cancer   MUTYH variants   biallelic inactivation   base excision repair   tumors  

Cross-Cancer Study Reveals Biallelic Inactivation of MUTYH and Base Excision Repair Defects in Different Types of Solid Tumors Research Background In daily life, cells are often exposed to endogenous and exogenous oxidative stress, originating from by-products of cellular respiration and various external compounds. MUTYH is a key component of the b...

Genomic Profiling of Rare Undifferentiated Sarcomatoid Subtypes of Pancreatic Carcinomas: In Search of Therapeutic Targets

Medicine, Medical Laboratory Science, Oncology, Life Sciences, Biochemistry, Immunology,
Undifferentiated Sarcomatoid Carcinoma   Pancreatic Cancer   Genomic Profiling   Therapeutic Targets   Immune Checkpoint Inhibitors  

Genomic Characteristics of a Rare Pancreatic Cancer Undifferentiated Sarcomatoid Carcinoma Subtype Academic Background Pancreatic Ductal Adenocarcinoma (PDAC) is one of the deadliest cancers, characterized by early invasion and metastasis. Undifferentiated Sarcomatoid Carcinoma (USC) is a particularly aggressive but rare subtype of PDAC, accounting...

High-Dimensional Mapping of Human CEACAM1 Expression on Immune Cells and Association with Melanoma Drug Resistance

Medicine, Oncology, Life Sciences, Cell Biology, Bioengineering, Immunology,
CEACAM1   immune cells   melanoma   drug resistance   tumor microenvironment   immune checkpoint  

The Expression of High-Dimensional Mapping of Human CEACAM1 on Immune Cells and Its Association with Melanoma Drug Resistance Research Background Human Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) is an inhibitory cell surface protein that acts through homophilic and heterophilic ligand binding. The expression of this protein...

Seeing an Apocalyptic Post-Antibiotic Future Lowers Antibiotics Expectations and Requests

Medicine, Infectious Diseases, Environmental and Public Health, Life Sciences, Immunology, Microbiology,
Antibiotic Resistance   Public Health Threat   Post-Antibiotic Era   Behavior Change   COVID-19 Pandemic   Consumer Behavior   Randomized Controlled Trial  

How to Reduce the Expectations and Demand for Antibiotics in the Face of the Threat of a “Post-Antibiotic Era” Introduction Antibiotic resistance is becoming a global public health threat. Although the evolution of this resistance is a biological process, human behavior, especially unnecessary antibiotic use in agricultural production and human med...