Research Report on the Association between Gene Variants and Neurocognitive Impairment in HIV Patients Over the past few decades, antiretroviral therapy (ART) has greatly improved the health of people infected with human immunodeficiency virus (HIV). However, even with effective viral suppression and partial immune system recovery, up to 50% of Peo...

Research Report on the Mechanism of Glycyrrhizic Acid in Alleviating Neurotoxicity Induced by Semen Strychni Background Introduction Semen Strychni, derived from the dried mature seeds of Strychnos Nux-vomica, has been found to possess various pharmacological activities, including anti-tumor, anti-inflammatory, immunosuppressive, and neuroexcitator...

The Sirtuin 5 Inhibitor MC3482 Ameliorates Microglia-Induced Neuroinflammation following Ischaemic Stroke by Upregulating the Succinylation Level of Annexin-A1 Background Ischaemic stroke is the most common type of stroke and a leading cause of death and disability worldwide. Its pathogenesis is complex, involving processes such as oxidative stress...

Overview of the Role of RhoA/ROCK/NF-κB Pathway in Microglial Polarization after Ischemic Stroke In recent years, ischemic stroke has become one of the leading causes of death and disability worldwide. However, effective treatments for ischemic stroke are still lacking. Studies have shown that microglia, as resident macrophages in the central nervo...

Research Report: The Protective Role of Gender on Pain Threshold and Neuroinflammatory Response in Allergic Rhinitis Model Background Introduction Allergic rhinitis (AR) is an inflammation of the nasal mucosa caused by allergens, affecting approximately 40% of the global population. Rhinitis not only causes physical discomfort but is also often acc...