β-hydroxybutyrate improves the redox status, cytokine production, and phagocytic potency of glucose-deprived HMC3 human microglia-like cells

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
β-hydroxybutyrate   HMC3   cytokines   glucose deprivation   human microglia   phagocytosis  

Research Report: β-Hydroxybutyrate Improves Redox State, Cytokine Secretion, and Phagocytic Ability of Glucose-Deprived HMC3 Human Microglia Introduction Microglia are resident neuroimmune cells in the brain, accounting for 5-12% of total neuroglial cells, with strong migration, proliferation, and phagocytic abilities. For example, microglia mainta...

Repetitive Administration of Low-Dose Lipopolysaccharide Improves Repeated Social Defeat Stress-Induced Behavioral Abnormalities and Aberrant Immune Response

Medicine, Psychiatry, Neurology, Clinical Psychology, Life Sciences, Biochemistry, Immunology,
lipopolysaccharide   social defeat stress   immune response   behavioral abnormalities   microglia  

Repeated Low-Dose Lipopolysaccharide Pretreatment Improves Behavioral Abnormalities and Aberrant Immune Responses Induced by Repeated Social Defeat Stress Background Stress significantly impacts human health, with chronic stress particularly inducing various physiological and psychological disorders. The hypothalamic-pituitary-adrenal (HPA) axis is...

Epigallocatechin-3-Gallate Inhibits LPS/AβO-Induced Neuroinflammation in BV2 Cells Through Regulating the ROS/Txnip/NLRP3 Pathway

Medicine, Basic Medical Sciences, Neurology, Pharmacy, Life Sciences, Cell Biology, Biochemistry,
Alzheimer's Disease   Amyloid β   Epigallocatechin-3-Gallate   NLRP3 Inflammasome   Txnip  

Epigallocatechin-3-Gallate (EGCG) Inhibits Neuroinflammation in BV2 Cells by Regulating the ROS/TXNIP/NLRP3 Pathway Research Background Alzheimer’s Disease (AD) is a degenerative brain disorder primarily affecting the elderly, characterized by persistent cognitive dysfunction and behavioral impairment. The neuropathological changes in AD include β-...

Gene Expression Alterations in the Spinal Cord of SIV-Infected Macaques on Antiretroviral Therapy

Medicine, Infectious Diseases, Neurology, Life Sciences, Cell Biology, Immunology,
SIV   HIV   spinal cord   antiretroviral therapy   gene expression   neuropathy  

NARP Laboratory Research Reveals the Impact of SIV Infection on Spinal Cord Gene Expression Background Despite the implementation of antiretroviral therapy (ART), HIV-associated peripheral neuropathy (HIV-DSP) remains one of the most common neurological manifestations of HIV infection. Clinical symptoms of HIV-DSP include weakness, numbness, burnin...

Antibiotics-Induced Intestinal Immunomodulation Attenuates Experimental Autoimmune Neuritis (EAN)

Medicine, Infectious Diseases, Rheumatology and Immunology, Neurology, Gastroenterology, Life Sciences, Immunology,
antibiotics   intestinal immunity   experimental autoimmune neuritis   immunomodulation   Guillain-Barré syndrome   gut microbiota  

Antibiotic-Induced Intestinal Immunomodulation Alleviates Experimental Autoimmune Neuritis (EAN) Academic Background Guillain-Barré syndrome (GBS) is an acute autoimmune disease that causes inflammatory demyelination of peripheral nerves. As the most common cause of acute flaccid paralysis, its global annual incidence is 1-4 cases per 100,000 peopl...