Fibrotic Response Induced by Anti-CSF-1R Treatment Promotes Glioblastoma Recurrence Background Introduction Glioblastoma (GBM) is a highly aggressive and malignant primary tumor of the central nervous system. Although current standard treatments include surgical resection, Temozolomide chemotherapy, and fractionated radiotherapy, the median surviva...
Background and Research Motivation Esophageal Squamous Cell Carcinoma (ESCC) is a highly aggressive cancer, especially in locally advanced stages. Traditional neoadjuvant chemoradiotherapy (NCRT) is the standard treatment method for this type of cancer. Despite its significant therapeutic effects, local recurrence and distant metastasis rates remai...
Role of Combined Anti-PD-1 and Anti-CTLA-4 Therapy in Melanoma Immune Response Background Immune checkpoint inhibitors have made significant progress in clinical oncology, especially anti-PD-1 (anti-programmed death protein 1) and anti-CTLA-4 (anti-cytotoxic T-lymphocyte-associated antigen 4) therapies, which have been proven to induce long-term re...
Background and Research Objectives High-Grade Glioma (HGG) is a highly lethal primary brain tumor with a particularly high incidence and mortality rate in children and adolescents. HGG can be further divided into several subtypes, among which Diffuse Hemispheric Glioma, H3G34-mutant (DHG-H3G34), is a rare subtype with poor prognosis, mainly occurri...
Background Glioblastoma (GBM) is a highly aggressive central nervous system malignancy with very poor prognosis, typically associated with short patient survival. Although significant advancements have been made in tumor treatment technologies and strategies in recent years, traditional radiotherapy and chemotherapy still struggle to achieve satisf...
Specific Tumor Structures and Microenvironment of Breast Cancer Metastasis to the Brain: A Research Review Research Background Brain metastasis is one of the severe complications faced by breast cancer patients, leading to complex neurological complications and low survival rates, with very limited treatment options. Among the various subtypes of b...