A PRM Mutation that Attenuates Dengue Virus Replication in Human Cells Enhances Midgut Infection in Mosquitoes

Medicine, Infectious Diseases, Life Sciences, Cell Biology, Immunology, Microbiology,
Dengue Virus   PRM Mutation   Virus Replication   Mosquito Infection   1970s   South Pacific   Epidemiology  

Dengue Virus Research: Impact of Genetic Mutations on Virus Transmission and Discoveries Introduction This study was conducted by Allyson N. X. Choi et al. and published in Science Translational Medicine on July 31, 2024. The research aims to reveal the impact of genetic changes in dengue virus on its transmission ability and disease outbreaks duri...

MGA Deletion Leads to Richter’s Transformation by Modulating Mitochondrial OXPHOS

Medicine, Basic Medical Sciences, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
MGA   Richter's transformation   mitochondria   OXPHOS   CLL  

MGA Deletion Promotes Richter’s Transformation by Regulating Mitochondrial Oxidative Phosphorylation This article mainly focuses on the transformation of chronic lymphocytic leukemia (CLL) into aggressive lymphoma, known as Richter’s Transformation (RT), exploring the function and molecular mechanism of MGA (MAX Gene Associated). MGA is a functiona...

Super-relaxed Myosins Contribute to Respiratory Muscle Hibernation in Mechanically Ventilated Patients

Medicine, Respiratory System, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Biophysics,
super-relaxed myosins   mechanical ventilation   respiratory muscle hibernation   ICU   diaphragm weakness  

The Impact of Super-Relaxed Myosin on Diaphragm Dysfunction in Ventilated Patients Background Weak diaphragm contraction is a common problem in patients receiving mechanical ventilation in intensive care units (ICUs). This leads to difficulties in weaning patients off ventilators, increases mortality rates, and imposes a significant economic burden...

Revisiting Distinct Nerve Excitability Patterns in Patients with Amyotrophic Lateral Sclerosis

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biophysics,
ion channels   amyotrophic lateral sclerosis   progression rate   composite measures   nerve excitability   emg  

“Revisiting Distinct Nerve Excitability Patterns in Patients with Amyotrophic Lateral Sclerosis” Academic Background Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive loss of central and peripheral motor neurons. Although the disease is clinically and genetically heterogeneous, axonal hy...

Engineered Exosomes with a Photoinducible Protein Delivery System Enable CRISPR-Cas–Based Epigenome Editing in Alzheimer’s Disease

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
engineered exosomes   photoinducible protein   Alzheimer’s disease   CRISPR-Cas   epigenome editing   delivery system   memory improvement  

CRISPR-Cas-Based Epigenome Editing in Alzheimer’s Disease: Engineered Exosomes with a Photoinducible Protein Delivery System Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by progressive decline in cognitive function and memory, with currently limited treatment options. Genome editing technologies, such as ...

Leptin Receptor Reactivation Restores Brain Function in Early-Life lepr-Deficient Mice

Medicine, Basic Medical Sciences, Endocrinology, Neurology, Neurosurgery, Life Sciences, Cell Biology, Biochemistry,
leptin   obesity   neurogenesis   memory impairment   brain atrophy  

Reactivation of Insulin Receptors Can Restore Brain Function in Early Lepr-Deficient Mice Background Obesity is a chronic disease caused by excessive fat accumulation, affecting both body and brain health. Deficiency of the insulin receptor (Leptin receptor, Lepr) is considered an important factor in the pathogenesis of obesity. Insulin plays a cru...