Integrated Analyses of Multi-Omic Data Reveal Metabolic Vulnerability as a Novel Therapeutic Target in Lung Cancer Brain Metastases

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
Lung cancer brain metastases   Metabolic vulnerability   Tumor immune microenvironment   Multi-omic analysis   Mitochondrial metabolism  

Report on the Multi-Omics Study of Lung Cancer Brain Metastases (LC-BMs) Academic Background Lung cancer is one of the most prevalent and deadly cancers worldwide. Lung cancer brain metastases (LC-BMs) are a common complication in patients with lung cancer and are associated with poor prognosis. Despite advances in lung cancer therapies, the standa...

Genome-aware annotation of CRISPR guides validates targets in variant cell lines and enhances discovery in screens

Medicine, Oncology, Life Sciences, Cell Biology, Bioengineering, Genetics,
CRISPR   genome annotation   bioinformatics   computational biology   software tool  

Genomic Medicine and Re-annotation of CRISPR Guides: Application and Validation of the EXORCISE Algorithm Academic Background The advent of CRISPR-Cas9 technology has revolutionized genetic screening, particularly in studying gene essentiality and chemo-genetic interactions. By designing guide RNAs (gRNAs) that target specific genes, the CRISPR-Cas...

Genomic Surveillance of Multidrug-Resistant Organisms Based on Long-Read Sequencing

Medicine, Infectious Diseases, Environmental and Public Health, Life Sciences, Genetics, Microbiology,
genomic surveillance   multidrug-resistant organisms   long-read sequencing   nanopore sequencing   MLST   WGMLST   WGS  

Genomic Surveillance of Multidrug-Resistant Organisms Based on Long-Read Sequencing Research Background Multidrug-resistant organisms (MDROs) are a significant global public health threat. These organisms exhibit resistance to multiple antibiotics, making infections challenging to treat and increasing healthcare costs. To effectively monitor and co...

CD30 Influences Germinal Center B-Cell Dynamics and the Expansion of IgG1-Switched B Cells

Medicine, Rheumatology and Immunology, Life Sciences, Cell Biology, Biochemistry, Immunology,
B lymphocytes   germinal center reaction   CD30   conditional mice   CD30L   senescence-associated T cells  

The Impact of CD30 on Germinal Center B Cell Dynamics and the Expansion of IgG1-Switched B Cells Background CD30 (also known as TNFRSF8) is a member of the tumor necrosis factor receptor (TNF-R) superfamily. Initially identified as a marker of Hodgkin lymphoma, subsequent research revealed its expression on other lymphomas, such as diffuse large B-...

Kynurenine-AHR Reduces T-Cell Infiltration and Induces a Delayed T-Cell Immune Response by Suppressing the STAT1-CXCL9/CXCL10 Axis in Tuberculosis

Medicine, Infectious Diseases, Life Sciences, Immunology,
tuberculosis   tryptophan metabolism   IDO1   immunosuppression   chemokines   T-cell infiltration   STAT1 signaling pathway  

Research Background and Motivation Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a global health issue infecting and killing millions annually. Despite advances in TB diagnosis and treatment, the immune evasion strategies employed by Mtb remain a critical reason for its prolonged survival in the host, leading to chronic infectio...