Tissue Factor Promotes TREX1 Protein Stability to Evade cGAS-STING Innate Immune Response in Pancreatic Ductal Adenocarcinoma Academic Background Pancreatic ductal adenocarcinoma (PDAC) remains one of the most challenging malignancies worldwide, with increasing incidence and mortality rates, particularly in advanced stages. Despite significant prog...

TFF3 Drives Hippo-Dependent EGFR-TKI Resistance in Lung Adenocarcinoma Academic Background Lung adenocarcinoma (LUAD) is one of the most common subtypes of non-small cell lung cancer (NSCLC), with frequent mutations in the epidermal growth factor receptor (EGFR). Since 2013, EGFR tyrosine kinase inhibitors (TKIs) such as gefitinib, erlotinib, and o...

TRIB3 Promotes Multiple Myeloma Progression by Stabilizing SSRP1 via USP10-Mediated Deubiquitination Academic Background Multiple Myeloma (MM) is the second most common hematologic malignancy globally, characterized by aggressive progression, frequent relapse, and resistance to therapy. Although current multi-drug combination therapies have signifi...

lgals9b Stabilizes eef1d Protein and Activates the PI3K/AKT Signaling Pathway to Promote Gastric Cancer Occurrence and Metastasis Academic Background Gastric cancer ranks as the fifth most prevalent cancer globally, with over one million new cases diagnosed annually. Due to late detection, it exhibits a high mortality rate and is the fourth leading...

Metabolic Rewiring Controlled by HIF-1α Tunes IgA-Producing B-Cell Differentiation and Intestinal Inflammation Background Introduction Germinal centers (GC) are critical sites for the clonal expansion of immune B cells and the affinity maturation of antibodies, as well as the occurrence of antibody class switching. Within the GC, B cells undergo so...