Report on the Academic Paper on the Monoclonal Antibody INCA033989 for Targeting Mutated Calreticulin in Myeloid Tumors Background: Calreticulin Mutation-Driven Myeloproliferative Neoplasms Myeloproliferative neoplasms (MPNs) are hematological malignancies caused by somatic mutations occurring in multipotent hematopoietic stem cells (HSCs). These m...

Revisited Diagnostic Guidelines for Familial Hemophagocytic Lymphohistiocytosis (FHL) Based on HLH-2004: Updates to Diagnostic Criteria and Development of Multipathway Diagnostic Strategies Introduction Familial hemophagocytic lymphohistiocytosis (FHL) is a severe hyperinflammatory disease characterized by abnormal accumulation of macrophages and l...

Review Report on the Paper: Structural Adaptations of Von Willebrand Factor, Factor VIII, and Factor IX to Coordinate Complex Functions Background and Research Motivation Coagulation factors are crucial elements of maintaining the dynamic balance of the hemostatic system. Among them, von Willebrand Factor (VWF) plays a central role in hemostasis, p...

Inhibition of JAK2/mTOR Fails to Effectively Prevent Acute Graft-versus-Host Disease (GVHD): Limitations of Targeting Th1/Th17 Cells In recent years, the role of systemic immunosuppressive therapies in preventing acute graft-versus-host disease (aGVHD) following allogeneic hematopoietic cell transplantation (alloHCT) has come under scrutiny. Th1 (T...

Whole-Genome Analysis of Plasma Fibrinogen Reveals Population-Differentiated Genetic Regulators with Potential Liver Roles Academic Background Fibrinogen is a crucial coagulation factor and acute-phase reactive protein. Under normal physiological conditions, fibrinogen is abundant in circulation, but during the acute inflammatory response, transcri...