Skin-Permeable Gold Nanoparticles with Azelamide Monoethanolamine Modifications Ameliorate Inflammatory Skin Diseases

Chemistry, Nanoscience, Medicinal Chemistry, Materials Science, Medicine, Rheumatology and Immunology, Life Sciences, Immunology,
gold nanoparticles   azelamide monoethanolamine   skin inflammation   topical therapeutics   oxidative stress   matrix metalloproteinase   superoxide dismutase  

Report on the Academic Paper Inflammatory skin diseases, such as psoriasis and rosacea, are common chronic skin conditions worldwide, significantly impacting patients’ quality of life. Traditional topical drug delivery methods, while simple and non-invasive, suffer from poor skin penetration and long-term side effects. Therefore, developing an effe...

Single-Cell Analysis Reveals Alterations Between the Aged and Young Mice Prostates

Medicine, Urology, Life Sciences, Cell Biology, Immunology,
Single-cell RNA sequencing   Prostate aging   Cellular heterogeneity   Gene expression   Mouse model  

Single-Cell Analysis Reveals Differences Between Aged and Young Mouse Prostates Academic Background The prostate is a vital component of the male reproductive system. As men age, the prostate undergoes hyperplasia, which can lead to urethral compression, resulting in voiding dysfunction and associated symptoms, as well as an increased risk of prost...

The Spatial Impact of a Western Diet in Enriching Galectin-1-Regulated Rho, ECM, and SASP Signaling in a Novel MASH-HCC Mouse Model

Medicine, Hepatobiliary System, Gastroenterology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Western Diet   Galectin-1   Rho Signaling   ECM Remodeling   SASP Signaling   MASH-HCC   Tumor Microenvironment  

The Spatial Impact of a Western Diet in Enriching Galectin-1-Regulated Rho, ECM, and SASP Signaling in a Novel MASH-HCC Mouse Model Academic Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and metabolic dysfunction-associated steatohepatitis (MASH) is one of the primary triggers of HCC. With ...

PEARL: A Phase Ib/II Biomarker Study of Adding Radiation Therapy to Pembrolizumab Before Neoadjuvant Chemotherapy in HER2-Negative Breast Cancer

Medicine, Oncology, Life Sciences, Immunology,
breast cancer   radiation therapy   Pembrolizumab   neoadjuvant chemotherapy   biomarkers   HER2-negative   tumor-infiltrating lymphocytes  

Academic Background Breast cancer is one of the most common cancers among women worldwide, particularly triple-negative breast cancer (TNBC) and hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer, which are known for their aggressive nature and poor prognosis. In recent years, immune checkpoint inh...

The Role of lncRNA-Mediated ceRNA Network in Penile Squamous Cell Carcinoma

Medicine, Urology, Oncology, Life Sciences, Immunology, Genetics,
long non-coding RNA   competing endogenous RNA network   penile squamous cell carcinoma   tumor microenvironment   immunosuppression  

The Role of lncRNA-Mediated ceRNA Network in Penile Squamous Cell Carcinoma Academic Background Penile Squamous Cell Carcinoma (PSCC) is a relatively rare but life-threatening malignancy that poses a significant health risk to men, particularly in developing countries. Despite advancements in medical diagnosis and treatment, the overall survival ra...