Magnetic Resonance-Guided Focused Ultrasound Thalamotomy Rebalances Atypical Functional Hierarchy in Patients with Essential Tremor

Medicine, Basic Medical Sciences, Neurology, Neurosurgery, Medical Imaging, Life Sciences, Biochemistry, Immunology,
magnetic resonance-guided   focused ultrasound   thalamotomy   essential tremor   functional gradient   brain functional framework   neuropathophysiology  

Research Report: Reshaping Functional Hierarchies in Medication-Refractory Essential Tremor Through MRgFUS Therapy Essential tremor (ET), a prevalent movement disorder, is characterized by involuntary limb tremors, particularly noticeable during specific tasks. While traditional pharmacological treatments and deep brain stimulation (DBS) have shown...

Therapeutic Effects of Combination of Nebivolol and Donepezil: Targeting Multifactorial Mechanisms in ALS

Chemistry, Medicinal Chemistry, Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Amyotrophic Lateral Sclerosis   Neurodegeneration   Multifactorial Mechanisms   Drug Combination Therapy   Motor Neuron Protection  

Report on ALS Treatment Study: Exploring the Multifaceted Mechanisms of Nebivolol and Donepezil Background and Research Objectives Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease marked by progressive loss of motor neurons in the spinal cord and brain, leading to severe muscle atrophy, functional decline, and eventual death...

Persistent NRG1 Type III Overexpression in Spinal Motor Neurons Has No Therapeutic Effect on ALS-Related Pathology in SOD1 G93A Mice

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology, Microbiology,
ALS   motor neurons   NRG1   SOD1   neurodegenerative disease   therapy   gene therapy  

Background and Research Motivation Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease affecting upper and lower motor neurons, leading to progressive muscle paralysis and eventual death. Currently, no effective treatments can significantly delay or halt ALS progression. While various ALS mouse models (such as those carry...

Intravenous Administration of an AAV9 Vector Ubiquitously Expressing C1ORF194 Gene Improved CMT-like Neuropathy in C1ORF194-/- Mice

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
CMT disease   C1ORF194   gene therapy   AAV9   neuropathy   motor ability   sensory nerves  

Research Report on the Improvement of CMT-like Neuropathy via AAV9 Vector-based C1ORF194 Gene Therapy Background and Research Motivation Charcot-Marie-Tooth disease (CMT) is a rare group of genetically heterogeneous neuromuscular disorders characterized by progressive muscle weakness and atrophy, along with sensory loss. Despite extensive preclinic...

Frequency-Dependent Reduction of Cybersickness in Virtual Reality by Transcranial Oscillatory Stimulation of the Vestibular Cortex

Information Science, Artificial Intelligence, Medicine, Neurology, Medical Imaging, Life Sciences, Bioengineering,
transcranial oscillatory stimulation   cybersickness   virtual reality   vestibular system   10Hz   neuromodulation   motion sickness  

Use of Transcranial Oscillatory Stimulation to Reduce Cybersickness in Virtual Reality Background and Motivation Virtual Reality (VR) technology is increasingly integrated into fields such as work, healthcare, and entertainment. However, approximately 95% of VR users experience symptoms known as Cybersickness (CS), characterized by nausea, dizzines...