Stem Cell Transplantation Extends the Reproductive Lifespan of Naturally Aging Cynomolgus Monkeys Background of the Study The ovary is a crucial organ for female reproduction and health, responsible for producing oocytes and secreting sex hormones. As women age, ovarian reserves gradually decline, eventually leading to menopause, which brings about...

Selective Advantage of Clonal Hematopoietic Mutant Stem Cells in Aging and Inflammatory Responses Background and Research Motivation Clonal Hematopoiesis (CH) is an aging-related phenomenon in the hematopoietic system, where hematopoietic stem cells (HSCs) acquire specific somatic mutations and undergo expansion, causing a particular mutated cell l...

Study of Somite Formation Model Based on Microfluidic System Background and Research Motivation The formation of somites plays a crucial role in vertebrate embryonic development, significantly influencing the layout and functionality of the embryonic musculoskeletal system. Somite formation involves the segmentation of bilateral presomitic mesoderm...

Lipid Metabolism Mechanisms in Neurodegenerative Diseases: A New Study on Multiple Sclerosis Multiple Sclerosis (MS) is a common inflammatory autoimmune demyelinating disease of the central nervous system (CNS). As the disease progresses, patients gradually experience neurological damage and disability. Although there have been advances in the trea...

Epitope Prime Editing Shields Hematopoietic Cells from CD123 Immunotherapy: A Novel Therapeutic Strategy for Acute Myeloid Leukemia Research Background and Problem Statement Acute Myeloid Leukemia (AML) is a malignant blood disease characterized by the abnormal differentiation of myeloid hematopoietic stem and progenitor cells (HSPCs). Its incidenc...