Effectiveness of Ocrelizumab in Primary Progressive Multiple Sclerosis: A Multicenter, Retrospective Real-World Study Background and Research Motivation Multiple sclerosis (MS) is a chronic, complex, inflammatory, and degenerative demyelinating disease primarily affecting the central nervous system (CNS). It can lead to neurological impairments in ...

Long-term Intravenous Anti-CD20 Antibody Therapy Assessment in a French Multiple Sclerosis Cohort Background and Research Motivation Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease affecting the central nervous system, leading to varying degrees of physical and cognitive impairment. Recent Phase II and III clinical trials of...

Optimized Nutritional Interventions Improve Muscle Fatigue, Strength, and Quality of Life in Patients with Primary Mitochondrial Disease Background Introduction Primary mitochondrial disease (PMD) encompasses a group of disorders caused by mutations in mitochondrial DNA or nuclear DNA, affecting systemic energy metabolism. The prevalence is approxi...

Overview of Nitroglycerin-Based Neuroprotection in Acute Ischemic Stroke: A Pilot Randomized Controlled Trial Review Background and Research Objectives Acute ischemic stroke (AIS) is one of the leading global causes of disability and death. Despite the significant improvement in vascular recanalization rates and patient outcomes achieved with moder...

Parkinson’s Disease Research Report: Beta Burst Behavior Analysis Using a Wavelet-Based Time-Frequency Detection Framework Background Parkinson’s disease (PD) is a prevalent neurodegenerative disorder characterized by motor dysfunction, including tremors, rigidity, and bradykinesia. Recent studies have linked motor impairments in PD to excessive sy...