Targeting SNRNP200-Induced Splicing Dysregulation as an Immunotherapy Opportunity for Glycolytic Triple-Negative Breast Cancer

Medicine, Infectious Diseases, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
triple-negative breast cancer   SNRNP200   glycolysis   metabolic dysregulation   immunotherapy  

Targeting SNRNP200-Induced Splicing Dysregulation: A New Strategy for Immunotherapy in Glycolytic Triple-Negative Breast Cancer Background Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, characterized by extremely high recurrence and mortality rates. Despite significant recent advances in research on TNBC subty...

Complex Mosaicism and Aneuploid Cells in Human Embryo Development

Medicine, Obstetrics and Gynecology, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Genetics,
human embryo   mosaicism   aneuploidy   single-cell sequencing   embryo development  

Study of Complex Mosaicism in Human Embryos: Revealing Extensive Aneuploidy During Early Embryonic Development Background and Research Objectives Pre-implantation Genetic Testing for Aneuploidy (PGT-A) is a widely used technology in in vitro fertilization (IVF) aimed at screening out abnormal embryos to improve implantation and live birth rates. Ho...

Mechanisms of MED23 in Regulating Oligodendrocyte Differentiation and Myelination

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics, Microbiology,
MED23   oligodendrocytes   myelination   nervous system   transcription regulation  

Cross-Disciplinary Breakthrough: How Mediator Med23 Regulates Molecular Mechanisms of Neural Myelination Background and Research Objective Myelin is the multilayered membrane structure that wraps around axons in the central nervous system (CNS), and its integrity is crucial for neural signal conduction and overall nervous system function. When myel...

Deciphering the Topological Landscape of Glioma: A Framework Based on Network Theory

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology, Genetics,
glioma   glioma stem cell   gene regulatory network   network dynamics   endogenous network theory   energy landscape  

Deciphering the Topological Landscape of Glioma: A Study Based on a Network Theory Framework Glioma stem cells (GSCs) are recognized as key factors in glioma recurrence and treatment resistance, making them an important focus for new therapeutic approaches. However, the limited understanding of the role of GSCs in the hierarchy of glioma has sparke...

Flow Cytometry Identifies Changes in Peripheral and Intrathecal Lymphocyte Patterns in CNS Autoimmune Disorders and Primary CNS Malignancies

Flow Cytometry Identifies Changes in Peripheral and Intrathecal Lymphocyte Patterns in CNS Autoimmune Disorders and Primary CNS Malignancies

Medicine, Rheumatology and Immunology, Medical Laboratory Science, Neurology, Medical Imaging, Oncology, Life Sciences, Immunology,
flow cytometry   central nervous system   autoimmune disorders   malignancies   lymphocytes   immunophenotyping   early diagnosis  

New Insights into CNS Disease Immunology Mechanisms Revealed by Multidimensional Flow Cytometry In immunological research, understanding the immunopathological mechanisms of central nervous system (CNS) diseases is crucial for early diagnosis and treatment decisions. A study published in Journal of Neuroinflammation in 2024 used multidimensional fl...