Sequence-Based Functional Metagenomics Reveals Novel Natural Diversity of Cu Resistance Gene copa in Environmental Microbiomes

Chemistry, Environmental Chemistry, Life Sciences, Biochemistry, Bioengineering, Microbiology,
Functional Metagenomics   Natural Diversity   Cu Resistance   Evolutionary Trace Analysis   Copper Tolerance  

Sequence-based Functional Metagenomics Reveals New Natural Diversity of Functional COPA Genes in Environmental Microbiomes The natural diversity of functional genes/proteins in environmental microbiomes is an essential component of evolutionary and bioengineering research. To gain a deeper understanding of the diversity of the copper (Cu) resistanc...

Decoding Human Biology and Disease Using Single-Cell Omics Technologies

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
single-cell omics   computational method   cellular heterogeneity   disease   cancer research  

Decoding Human Biology and Disease with Single-Cell Omics Technologies Background Introduction Cells are the fundamental units of life. A single fertilized egg can develop into an entire complex human body, composed of approximately 37 trillion cells organized into various tissues, organs, and systems. Traditional cell classification methods primar...

Novel Time-Dependent Multi-Omics Integration in Sepsis-Associated Liver Dysfunction

Medicine, Infectious Diseases, Hepatobiliary System, Medical Laboratory Science, Life Sciences, Biochemistry, Genetics,
multi-omics   omics technology   sepsis-associated liver dysfunction   single omics   time-dependent integration  

Time-Dependent Multi-Omics Integration in Sepsis-Associated Liver Dysfunction Introduction Sepsis, especially severe cases, causes multiple organ dysfunction due to systemic infection, resulting in up to 5 million deaths globally each year. Traditionally, Sepsis-Associated Liver Dysfunction (SALD) was considered a condition accompanied by jaundice ...

Protein Structure Prediction: Challenges, Advances, and the Shift of Research Paradigms

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Cell Biology, Biochemistry, Biophysics,
protein folding   protein structure prediction   deep learning   transformer   language model  

Protein Structure Prediction: Challenges, Progress, and Shifts in Research Paradigms Protein structure prediction is an important interdisciplinary research topic that has attracted researchers from various fields including biochemistry, medicine, physics, mathematics, and computer science. Researchers have adopted multiple research paradigms to so...

Patient Assessment and Therapy Planning Based on Homologous Recombination Repair Deficiency

Medicine, Oncology, Life Sciences, Cell Biology, Genetics,
Homologous recombination repair deficiency   DNA damage response   Biomarker   PARP inhibitors   Gene mutations   Cancer therapy   Genomic scars  

Application of Homologous Recombination Deficiency (HRD) in Tumor Patient Assessment and Treatment Planning Background Homologous Recombination (HR) is an important mechanism for repairing DNA Double-Strand Breaks (DSBs). However, when key genes in the HR repair pathway are mutated or epigenetically inactivated, cells are unable to effectively repa...