Intracranial electroencephalography reveals effector-independent evidence accumulation dynamics in multiple human brain regions

Academic News Report: Revealing Effector-Independent Evidence Accumulation Dynamics from Intracranial Electrophysiological Recordings Research Background The neural mechanisms underlying the decision-making process have long been a significant topic in neuroscience. Previous studies have indicated that it is possible to identify neural signals rela...

Dopamine and Serotonin in Human Substantia Nigra Track Social Context and Value Signals During Economic Exchange

Dopamine and Serotonin in Human Substantia Nigra Track Social Context and Value Signals During Economic Exchange

Background Introduction In contemporary neuroscience research, dopamine and serotonin are hypothesized to be crucial neuromodulators guiding social behavior. However, there is a significant lack of understanding regarding the dynamic changes of these neuromodulators during social interactions. Although non-invasive functional neuroimaging methods (...

Prediction of tumor origin in cancers of unknown primary origin with cytology-based deep learning

Prediction of tumor origin in cancers of unknown primary origin with cytology-based deep learning

Background Introduction Cancer of Unknown Primary (CUP) is a type of malignant disease that is confirmed to be metastatic through histopathology but whose primary site cannot be identified using conventional baseline diagnostic methods. CUP presents significant diagnostic and therapeutic challenges in clinical practice and is believed to account fo...

An Autoantibody Signature Predictive for Multiple Sclerosis

An Autoantibody Signature Predictive for Multiple Sclerosis

Predictive Autoantibody Signature for Multiple Sclerosis Academic Background and Research Significance Multiple Sclerosis (MS) is a chronic inflammatory autoimmune disease that primarily affects the white matter of the central nervous system (CNS). Previous studies have mostly suggested that T cells play a major role in the pathogenesis of MS. Howe...

Intrathecal Bivalent CAR T Cells Targeting EGFR and IL13Rα2 in Recurrent Glioblastoma: Phase 1 Trial Interim Results

Intrathecal Bivalent CAR T Cells Targeting EGFR and IL13Rα2 in Recurrent Glioblastoma: Phase 1 Trial Interim Results

The Effectiveness of Bivalent CAR T-Cell Therapy Targeting EGFR and IL13Rα2 in Treating Recurrent Glioblastoma In recent years, the treatment of recurrent glioblastoma (RGBM) has been continually explored and improved, yet overall survival rates remain less than one year, presenting a significant challenge. The limitations of existing treatments an...