Research Background The core focus of this study is the manifestation of gray matter atrophy in neuroinflammatory diseases. Gray matter atrophy typically appears in four types of neuroinflammatory demyelinating diseases: Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorders (NMOSD) positive (AQP4+) and negative (AQP4-) for aquaporin-4 an...

In recent years, Alzheimer’s disease (AD) has become a significant health problem affecting the elderly population worldwide. Its related neuropathological changes can begin decades before the appearance of clinical symptoms. To explore more comprehensively the relationship between AD risk and brain morphology, a research team conducted a bidirecti...

GLP-1-Directed NMDA Receptor Antagonism for Obesity Treatment In recent decades, obesity has become a global health problem, seriously affecting the quality of life and health of millions of people. Obesity is not only associated with numerous health issues such as diabetes, hypertension, and cardiovascular diseases but also severely impacts mental...

Dimond: A Study on Optimizing Diffusion Models through Deep Learning Academic Background In brain science and clinical applications, Diffusion Magnetic Resonance Imaging (dMRI) is an essential tool for non-invasively mapping the microstructure and neural connectivity of brain tissue. However, accurately estimating parameters of the diffusion signal...

Integrated Molecular and Spatial Analysis Reveals Evolutionary Dynamics and Tumor-Immune Interactions in In Situ and Invasive Acral Melanoma Academic Background of the Paper Melanoma is a type of skin cancer, and acral melanoma (AM) is a kind that occurs on non-exposed areas such as the palms, soles, and under the nails and is particularly common a...