Biomarkers Associated with the Progression of Infantile Hemangioma: An Exploratory Study Academic Background Infantile Hemangioma (IH) is one of the most common benign tumors in infancy. Although most IH is not apparent at birth, it gradually manifests within the first month of life and undergoes a proliferative phase over approximately one year, f...

Real-World 52-Week Effectiveness Study of Deucravacitinib in Psoriasis Background Introduction Psoriasis is a chronic inflammatory skin disease with a global prevalence of approximately 1% to 3%. This condition not only affects patients’ quality of life (QoL) but is also often accompanied by comorbidities such as cardiovascular diseases, diabetes, ...

History and Prospects of Nagashima-Type Palmoplantar Keratosis Background Palmoplantar keratoderma (PPK) is a group of hereditary or inflammatory skin disorders characterized by hyperkeratosis of the palms and soles, with diverse clinical manifestations and complex diagnostic criteria. Nagashima-type palmoplantar keratosis (NPPK) is the most common...

Stochastic Modeling of Single-Cell Gene Expression Adaptation Reveals Non-Genomic Contribution to Tumor Subclone Evolution Academic Background Cancer is a complex disease whose progression is driven by the evolution of cells that are selected through adaptive advantages for growth. Traditionally, cancer evolution research has focused primarily on g...

New Breakthrough in T Cell Receptor (TCR) Specificity Prediction: The Introduction of the SCEPTR Model Academic Background T cell receptors (TCRs) play a crucial role in the immune system by determining the specificity of immune responses through their binding to peptide-MHC complexes (pMHCs). Understanding the interaction between TCRs and specific...