Tumour Microenvironment-Mediated Drug Resistance in Neuroblastoma

Medicine, Pediatrics, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Neuroblastoma   Drug Resistance   Tumour Microenvironment   TGF-β1   Nuclear Factor-κB   Therapy  

Background Research Background: Both intrinsic and extrinsic factors in the tumor microenvironment (TME) can lead to treatment resistance. This paper reveals that the Transforming Growth Factor (TGF)-β1 produced within the TME increases drug resistance in neuroblastoma (NB) cells. Drug resistance is the main cause of cancer treatment failure, usual...

Plasma Membrane Damage Limits Replicative Lifespan in Yeast and Induces Premature Senescence in Human Fibroblasts

Medicine, Geriatrics, Life Sciences, Cell Biology, Biochemistry, Immunology,
plasma membrane damage   replicative lifespan   premature senescence   yeast   fibroblasts  

Scientific Research Report: Plasma Membrane Damage Limits Yeast Replicative Lifespan and Induces Premature Senescence in Human Fibroblasts Background and Research Motivation Plasma Membrane Damage (PMD) is a phenomenon experienced by all cell types in response to environmental disturbances and spontaneous cellular activities. Previous studies have ...

HLA-A+ Tertiary Lymphoid Structures with Reactivated Tumor-Infiltrating Lymphocytes Are Associated with a Positive Immunotherapy Response in Esophageal Squamous Cell Carcinoma

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
HLA-A+   Tertiary Lymphoid Structures   Esophageal Squamous Cell Carcinoma   Immunotherapy   Tumor-Infiltrating Lymphocytes   Antigen Presenting Machinery   Gene Expression  

In esophageal squamous cell carcinoma (ESCC), immune checkpoint blockade (ICB) therapy has achieved significant clinical benefits. However, the overall response rate to ICB treatment remains low. This study aims to identify biomarkers for ESCC response to ICB therapy and explore their potential clinical relevance. The authors of the paper come from...

Epigenetic Activation of SOX11 is Associated with Recurrence and Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
SOX11   Ductal Carcinoma In Situ   Invasive Breast Cancer   Recurrence   Epigenetics   Biomarker   Progression  

Epigenetic Activation of Sox11 in Recurrence and Progression of Ductal Carcinoma In Situ Background Ductal Carcinoma In Situ (DCIS) is a non-invasive breast cancer characterized by the excessive proliferation of luminal epithelial cells surrounded by myoepithelial cells. DCIS accounts for approximately 25% of breast cancer screenings, and its poten...

Modeling of Glioma Growth with Mass Effect by Longitudinal Magnetic Resonance Imaging

Mathematics, Medicine, Medical Laboratory Science, Medical Imaging, Oncology, Life Sciences, Cell Biology, Bioengineering,
glioma   mass effect   tumor growth   magnetic resonance imaging   mathematical model  

Study of Mathematical Models for Tumor Growth – Exploring Glioma Extension Using Longitudinal Magnetic Resonance Imaging A recent article published in the IEEE Transactions on Biomedical Engineering presents a systematic study on the mathematical modeling and growth patterns of gliomas (glioma). This research was conducted by Birkan Tunç, David A. ...

Phosphocreatine Promotes Epigenetic Reprogramming to Facilitate Glioblastoma Growth through Stabilizing BRD2

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry,
Phosphocreatine   Glioblastoma   Epigenetic   BRD2   Growth Promotion  

The research results, completed in collaboration by many scientists including Lishu Chen, Qinghui Qi, and Xiaoqing Jiang, were published in the groundbreaking journal Cancer Discovery. The report detailed how phosphocreatine (PCr) promotes the growth of glioblastoma (GBM) by stabilizing bromodomain-containing protein 2 (BRD2). This discovery provid...