Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases

Medicine, Infectious Diseases, Medical Laboratory Science, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Alzheimer's disease   dementia   extracellular vesicles   neuroprotection   prions   proteolytic processing  

ADAM10-Mediated Human Prion Protein Cleavage and Its Relationship with Neurodegenerative Diseases Background The endopeptidic processing of multifunctional proteins is crucial for regulating their physiological functions and plays a significant role in various pathological conditions. Prion protein (PrP), a widely expressed glycosylphosphatidylinos...

Identification of Retinal Oligomeric, Citrullinated, and Other Tau Isoforms in Early and Advanced AD and Relations to Disease Status

Medicine, Medical Laboratory Science, Neurology, Ophthalmology, Life Sciences, Cell Biology, Biochemistry,
retinal biomarkers   tauopathy   frontotemporal lobar dementia   dementia with Lewy bodies   neurodegenerative diseases  

Research Report on Abnormal Tau Proteins in the Retina of Alzheimer’s Disease Patients Introduction Alzheimer’s disease (AD) is the primary cause of dementia in the elderly population worldwide. The pathological features of AD include the deposition of amyloid beta-protein (Aβ) and the aggregation of abnormal microtubule-associated tau proteins in ...

DNA methylation patterns in the frontal lobe white matter of multiple system atrophy, Parkinson’s disease, and progressive supranuclear palsy: a cross-comparative investigation

Medicine, Medical Laboratory Science, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Parkinsonian disorders   Multiple system atrophy   Parkinson’s disease   Progressive supranuclear palsy   DNA methylation   EWAS   WGCNA  

Cross-Comparative Study of DNA Methylation Patterns in the Frontal Lobe White Matter of Multiple System Atrophy, Parkinson’s Disease, and Progressive Supranuclear Palsy Academic Background Multiple System Atrophy (MSA) is a rare neurodegenerative disease characterized by neuronal loss and gliosis, accompanied by glial cytoplasmic inclusions (GCIs) ...

Characterisation of Premature Cell Senescence in Alzheimer’s Disease Using Single Nuclear Transcriptomics

Characterisation of Premature Cell Senescence in Alzheimer’s Disease Using Single Nuclear Transcriptomics

Medicine, Basic Medical Sciences, Geriatrics, Neurology, Life Sciences, Cell Biology, Biochemistry,
Aging   Senescence   Glia   Alzheimer’s Disease   Single Cell Transcriptomics   Image Mass Cytometry   Senolytics  

Characteristics of Premature Cellular Senescence in Alzheimer’s Disease: Application of Single-Nucleus Transcriptomics Research Background and Objectives Alzheimer’s disease (AD) is the most common type of dementia in the elderly, characterized by extracellular deposition of β-amyloid protein and intracellular neurofibrillary tangles. Other patholo...

Amyloid-β peptide signature associated with cerebral amyloid angiopathy in familial Alzheimer’s disease with APPdup and Down syndrome

Medicine, Medical Laboratory Science, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Alzheimer’s disease   Down syndrome   Aβ peptides   cerebral amyloid angiopathy   mass spectrometry   neuropathology  

Background Introduction Alzheimer’s disease (AD) is an age-related neurodegenerative disease characterized by the death of neurons in the brain. Its main pathological features include extracellular β-amyloid plaques and intracellular neurofibrillary tangles (NFTs). β-amyloid plaques are primarily composed of aggregated Amyloid beta peptides (Aβ). A...

Neuropathologically Directed Profiling of PRNP Somatic and Germline Variants in Sporadic Human Prion Disease

Medicine, Infectious Diseases, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
prion disease   Creutzfeldt-Jakob disease   somatic mutation   PRNP   genetics  

Somatic and Germline PRNP Variants in Sporadic Human Prion Disease: A Neuropathological Study Introduction Prion diseases are a class of infectious, progressive, and fatal neurodegenerative diseases characterized by the pathological folding and aggregation of prion protein (PrP). Prion protein is encoded by the PRNP gene, with normal cellular prion...