High Concordance of Different Assays in the Determination of Homologous Recombination Deficiency–Associated Genomic Instability in Ovarian Cancer

High Concordance of Different Assays in the Determination of Homologous Recombination Deficiency–Associated Genomic Instability in Ovarian Cancer

Medicine, Medical Laboratory Science, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
Homologous Recombination Deficiency   Ovarian Cancer   Genomic Instability   Biomarkers   PARP Inhibitors  

Ovarian cancer is one of the most common and deadly tumor types in women. In recent years, Poly (ADP-ribose) polymerase inhibitors (PARPi) have shown encouraging clinical results in the treatment of ovarian cancer. Numerous studies have found that patients with homologous recombination deficiency (HRD) benefit more from PARPi treatment. Therefore, ...

Analysis of Breast Cancer Brain Metastases Reveals an Enrichment of Cyclin-Dependent Kinase 12 Structural Rearrangements in Human Epidermal Growth Factor Receptor 2–Positive Disease

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
breast cancer   brain metastasis   structural rearrangement   cyclin-dependent kinase 12   HER2   genomics   targeted therapy  

Research Report on CDK12 Structural Rearrangements in Brain Metastases of Breast Cancer Background and Purpose Breast Cancer (BC) is the second most common solid tumor involving the Central Nervous System (CNS). Brain Metastases from Breast Cancer (BCBMs) are becoming increasingly common among patients with metastatic breast cancer. Patients with a...

High-Dimensional Mapping of Human CEACAM1 Expression on Immune Cells and Association with Melanoma Drug Resistance

Medicine, Oncology, Life Sciences, Cell Biology, Bioengineering, Immunology,
CEACAM1   immune cells   melanoma   drug resistance   tumor microenvironment   immune checkpoint  

The Expression of High-Dimensional Mapping of Human CEACAM1 on Immune Cells and Its Association with Melanoma Drug Resistance Research Background Human Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) is an inhibitory cell surface protein that acts through homophilic and heterophilic ligand binding. The expression of this protein...

Aging-Induced MCPH1 Translocation Activates Necroptosis and Impairs Hematopoietic Stem Cell Function

Medicine, Medical Laboratory Science, Geriatrics, Hematology, Life Sciences, Cell Biology, Biochemistry,
Aging   MCPH1   Necroptosis   Hematopoietic Stem Cells   DNA Damage   Nuclear Translocation   Gene Function  

Study on MCPH1 Nuclear Transfer Induced by Aging Activating Necrosis and Impairing Hematopoietic Stem Cell Function Research Background The aging of hematopoietic stem cells is associated with an increased risk of various blood diseases, and DNA damage is a significant factor driving the aging of hematopoietic stem cells. However, the underlying mo...

Estrogen Counteracts Age-Related Decline in Beige Adipogenesis Through the NAMPT-Regulated ER Stress Response

Medicine, Basic Medical Sciences, Geriatrics, Endocrinology, Life Sciences, Cell Biology, Biochemistry,
Estrogen   NAMPT   ER Stress Response   Beige Adipogenesis   Metabolic Diseases   Energy Expenditure  

Reversal of Beige Fat Decline by Estrogen Through NAMPT-Regulated Endoplasmic Reticulum Stress Response Abstract: Brown adipocytes are valued for their potential therapeutic effects against metabolic diseases. However, the metabolic advantages provided by these cells deteriorate with age. Our research shows that treating mice with estrogen (E2), a ...

A Single-Nuclei Paired Multiomic Analysis of the Human Midbrain Reveals Age- and Parkinson’s Disease–Associated Glial Changes

A Single-Nuclei Paired Multiomic Analysis of the Human Midbrain Reveals Age- and Parkinson’s Disease–Associated Glial Changes

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Parkinson's disease   single-nuclei paired analysis   multiomic analysis   human midbrain   age-related changes   glial cells   chromatin accessibility  

Single-nucleus Multi-omics Analysis Reveals Age-related and Parkinson’s Disease-related Changes in Neuroglia in the Human Midbrain Research Background Age is a major risk factor for Parkinson’s Disease (PD). Although the significant role of age in PD onset is known, details about how age alters the gene expression and regulatory landscape of the br...