Dissecting Gene Expression Networks in the Developing Hippocampus through the Lens of NEIL3 Depletion

Dissecting Gene Expression Networks in the Developing Hippocampus through the Lens of NEIL3 Depletion

Analyzing the Gene Expression Network in Developing Hippocampus from the Perspective of NEIL3 Deficiency Background The hippocampus, a crucial region of the brain, is well-regarded for its key roles in memory consolidation, information processing, and emotional regulation. In the field of neuroscience research, the gene regulatory mechanisms of the...

Chronic Evoked Seizures in Young Pre-symptomatic APP/PS1 Mice Induce Serotonin Changes and Accelerate Onset of Alzheimer’s Disease-Related Neuropathology

APP/PS1 Mouse Study Reveals Link Between Chronic Induced Epilepsy and Alzheimer’s Disease Background Alzheimer’s Disease (AD) is the most common type of dementia globally, affecting over 55 million people. The typical pathological feature of AD is the deposition of amyloid-β (Aβ) in the brain. Although Aβ deposition and the mechanisms it triggers p...

Central C3a Receptor Modulates LPS-Induced Depressive-like Behaviors

The Regulatory Mechanism of Central Complement C3a Receptor on LPS-Induced Depressive-Like Behavior Introduction With the increasing number of depression patients globally, major depressive disorder (MDD) has become one of the leading causes of disability worldwide. The symptoms, treatment effects, and biological correlations of depression exhibit ...

Mixed Selectivity in Monkey Anterior Intraparietal Area During Visual and Motor Processes

Research Report on Mixed Selectivity in Monkey Anterior Intraparietal Area During Visual and Motor Processes Background In recent years, the anterior intraparietal area (AIP) has garnered significant interest in the field of neuroscience. AIP is considered a convergence node for multiple visual and somatosensory information, including the physical ...

Lateralization of Dorsal Fiber Tract Targeting Broca’s Area Concurs with Language Skills During Development

Lateralization of Dorsal Fiber Tract Targeting Broca’s Area Concurs with Language Skills During Development

New Discoveries in Brain Science: The Relationship Between Early Lateralization of Dorsal White Matter Tracts Targeting Broca’s Area and Language Development Research Background Language development is one of the key areas in human cognitive science. Existing research indicates that language functions in the adult brain exhibit significant laterali...

Decoding the Influence of Central LEAP2 on Food Intake and Its Effect on Accumbal Dopamine Release

Analysis of the Effect of Central LEAP-2 on Food Intake and Its Impact on Nucleus Accumbens Dopamine Release Background Introduction Gut-brain peptides such as ghrelin and their receptors have been established as important factors in regulating hunger and reward processing. However, the liver-expressed antimicrobial peptide 2 (Leap2), an inverse ag...