Identification of Lineage-Specific Epigenetic Regulators FOXA1 and GRHL2 through Chromatin Accessibility Profiling in Breast Cancer Cell Lines

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Breast Cancer   Epigenetics   Chromatin Accessibility   FOXA1   GRHL2   Cell Lines   Heterogeneity  

Identification of Lineage-Specific Epigenetic Regulators FOXA1 and GRHL2 through Chromatin Accessibility Analysis of Breast Cancer Cell Lines Background Breast cancer is a highly heterogeneous disease currently classified clinically based on gene expression patterns, intrinsic molecular subtypes, and the expression of hormone receptors/human epider...

Adeno-Associated Virus-Mediated Trastuzumab Delivery to the Central Nervous System for Human Epidermal Growth Factor Receptor 2+ Brain Metastasis

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
Adeno-Associated Virus   Trastuzumab   Central Nervous System   Brain Metastasis   Gene Therapy   Breast Cancer   HER2  

AAV-Mediated Trastuzumab Delivery to the Central Nervous System for EGFR2-Positive Brain Metastases Introduction In the treatment of breast cancer, tumors that are human epidermal growth factor receptor 2 (HER2) positive exhibit more aggressive characteristics, posing significant challenges for clinical treatment. Since the approval of trastuzumab ...

Phase-dependent word perception emerges from region-specific sensitivity to the statistics of language

Phase-dependent word perception emerges from region-specific sensitivity to the statistics of language

Medicine, Basic Medical Sciences, Neurology, Clinical Psychology, Life Sciences, Cell Biology, Biophysics,
neural oscillations   language perception   phase coding   neural representations   speech perception  

Phase-Dependent Language Perception in Neural Oscillations: An Interdisciplinary Study Report Background During speech perception, the phase of neural oscillations plays a crucial role in the separation of neural representations and perceptual decisions. However, the specific phase-encoding mechanisms remain unclear. This study aims to reveal how p...

SIRT1-RAB7 Axis Attenuates NLRP3 and STING Activation through Late Endosomal-Dependent Mitophagy during Sepsis-Induced Acute Lung Injury

Medicine, Infectious Diseases, Respiratory System, Life Sciences, Cell Biology, Biochemistry, Immunology,
acute lung injury   mitophagy   sepsis   SIRT1  

The SIRT1-Rab7 Axis Regulates NLRP3 and STING Activation in Sepsis-Induced Acute Lung Injury via Terminal Endosome-Dependent Mitophagy Academic Background Acute lung injury (ALI) is one of the leading causes of death in septic patients, primarily due to the pro-inflammatory changes and permeability defects in endothelial cells (ECs). Mitochondrial ...

Gliomatosis cerebri in children: a poor prognostic phenotype of diffuse gliomas with a distinct molecular profile

Medicine, Pediatrics, Medical Laboratory Science, Neurology, Oncology, Life Sciences, Cell Biology, Genetics,
pediatric gliomatosis cerebri   diffuse gliomas   molecular profile   poor prognosis   genetic alterations   high-grade gliomas   brain tumor  

Childhood Gliomatosis Cerebri: A Poor Prognosis Phenotype of Diffuse Glioma with Distinct Molecular Characteristics Introduction Gliomatosis cerebri (GC) is a highly invasive form of diffuse glioma. It was initially discarded as an independent pathological type due to its indeterminate molecular characteristics. However, with the advancements in mo...

Raman-Based Machine Learning Platform Reveals Unique Metabolic Differences Between IDHmut and IDHwt Glioma

Information Science, Artificial Intelligence, Medicine, Medical Laboratory Science, Neurology, Medical Imaging, Oncology, Life Sciences, Cell Biology, Biochemistry,
Raman spectroscopy   glioma   machine learning   FFPE tissue   lipid metabolism  

Study on Metabolic Differences between IDH Mutant and Wild-type Glioma Cells Using Raman Spectroscopy and Machine Learning Platform Background Introduction In the diagnosis and treatment of gliomas, formalin-fixed, paraffin-embedded (FFPE) tissue sections are commonly used. However, due to background noise interference from the embedding medium, th...