CD28 Costimulation Augments CAR Signaling in NK Cells via the Lck/CD3ζ/ZAP70 Signaling Axis

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
CD28   CAR-NK cells   Cancer Therapy   Signaling   Lck   ZAP70   Cytotoxicity  

The Costimulatory Role of CD28 Enhances the Function of CAR-NK Cells through the LCK/CD3ζ/ZAP70 Signaling Axis Research Background and Objective Chimeric Antigen Receptor (CAR) T-cell therapy has shown significant effects in treating certain advanced cancer patients. However, CAR-T cell therapy has many limitations, such as high cost, complex prepa...

CRISPR dependency screens in primary hematopoietic stem cells identify KDM3B as a genotype-specific vulnerability in IDH2- and TET2-mutant cells

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Biochemistry,
hematopoietic stem cells   KDM3B   epigenetics   clonal hematopoiesis   CRISPR screens   acute myeloid leukemia  

CRISPR-Dependent Screening in Primary Hematopoietic Stem Cells Identifies KDM3B as Specific Susceptibility for IDH2 and TET2 Mutant Genotypes Background and Significance Clonal Hematopoiesis (CH) refers to the abnormal growth of genetically distinct subclones of cells initiated by specific mutations in Hematopoietic Stem Cells (HSCs). This phenomen...

Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer

Medicine, Hepatobiliary System, Oncology, Life Sciences, Cell Biology, Biochemistry,
Pancreatic Cancer   KRAS   Resistance   Oncogenes   Cancer Research  

Mechanisms of Resistance to Carcinogenic KRAS Inhibition in Pancreatic Cancer Background Pancreatic Ductal Adenocarcinoma (PDAC) is a highly lethal disease. Most patients are diagnosed at an advanced stage and typically die within 12 months, primarily due to limited treatment options and poor response to standard chemotherapy. KRAS is the most crit...

Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

Medicine, Basic Medical Sciences, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry,
Acute Myeloid Leukemia   Stem Cells   Mitochondrial Calcium   Oxidative Phosphorylation   Drug Resistance  

This is an academic paper report on the study of acute myeloid leukemia (AML) stem cells. The study found that venetoclax treatment targeting the BCL-2 protein induces different mitochondrial calcium signaling changes in drug-sensitive and drug-resistant AML stem cells, thereby affecting their oxidative phosphorylation metabolism and survival. The ...

Mechanisms of Response and Tolerance to Active RAS Inhibition in KRAS-Mutant NSCLC

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry,
KRAS   mutations   NSCLC   active RAS inhibition   drug-tolerant persisters  

Response and Resistance Mechanisms of RAS Inhibitors in KRAS-Mutant NSCLC Research Background With the clinical development of RAS inhibitors, the treatment of KRAS-mutant Non-Small Cell Lung Cancer (NSCLC) faces a new turning point. However, in clinical practice, patients show poor long-term responses to RAS inhibitors, influencing clinical effica...

Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors

Medicine, Respiratory System, Oncology, Life Sciences, Biochemistry, Genetics,
MET   kinase domain   point mutation   lung cancer   malignancies   targeted therapy  

This study reveals a new targetable cancer subtype characterized by activating point mutations in the MET tyrosine kinase domain (TKD). Researchers identified MET TKD activating mutations in approximately 0.5% of patients across a genomic data set of over 600,000 cancer cases, encompassing various tumor types, with the highest prevalence in renal c...