A prognostic neural epigenetic signature in high-grade glioma

Medicine, Neurology, Neurosurgery, Oncology, Life Sciences, Cell Biology, Biochemistry,
glioma   neural epigenetics   prognostic signature   tumor biology   neuroscience  

Study of Neuroepithelial Genetic Markers and Prognosis in High-Grade Gliomas Background and Research Motivation High-grade gliomas are highly malignant brain tumors with generally poor patient prognosis. Previous preclinical model studies have suggested that interactions between neural and tumor cells drive tumor growth, but clinical validation of ...

Beta to Theta Power Ratio in EEG Periodic Components as a Potential Biomarker in Mild Cognitive Impairment and Alzheimer's Dementia

Medicine, Basic Medical Sciences, Neurology, Medical Imaging, Life Sciences, Biochemistry,
Alzheimer's dementia   mild cognitive impairment   EEG   periodic EEG power components   biomarkers   cognitive function  

Alzheimer’s Disease Research and Treatment Frontiers: Beta/Theta Power Ratio in EEG Periodic Components as a Potential Biomarker Background Introduction Alzheimer’s dementia (AD) is a progressively developing disease, accounting for 60% to 80% of all dementia cases [1]. In the early stages of AD, mild cognitive impairment (MCI) typically occurs, du...

Theta Oscillations Support Prefrontal-Hippocampal Interactions in Sequential Working Memory

Medicine, Neurology, Neurosurgery, Life Sciences, Cell Biology, Biochemistry, Biophysics,
sequential working memory   hippocampus   dorsolateral prefrontal cortex   theta oscillations   stereoelectroencephalography   phase coherence   granger causality  

Study on Theta Oscillations in Hippocampus-Prefrontal Interaction Supporting Sequential Working Memory Academic Background The dorsolateral prefrontal cortex (DLPFC) and the hippocampus play crucial roles in sequential working memory, but the specific interaction mechanisms are not yet clear. Previous studies have shown that these two brain regions...

Increases in Pre-Stimulus Theta and Alpha Oscillations Precede Successful Encoding of Crossmodal Associations

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Biochemistry, Biophysics,
EEG   theta oscillations   alpha oscillations   pre-stimulus interval   crossmodal associations   episodic memory   phase-based connectivity  

Enhancement of Theta and Alpha Oscillations Prior to Crossmodal Memory Encoding Background Episodic memory is a crucial component of human memory, with one of its core mechanisms being the formation of associations through stimuli from different sensory channels. Current theories suggest that during crossmodal associative encoding, the phase and po...

Hierarchical Negative Sampling Based Graph Contrastive Learning Approach for Drug-Disease Association Prediction

Information Science, Computer Science, Artificial Intelligence, Medicine, Pharmacy, Life Sciences, Biochemistry,
Drug-Disease Association   Contrastive Learning   Graph Neural Networks   Negative Sampling   Heterogeneous Network  

Research on Drug-Disease Association Prediction Using Graph Contrastive Learning Based on Layered Negative Sampling The prediction of drug-disease associations (RDAs) plays a critical role in unveiling disease treatment strategies and promoting drug repurposing. However, existing methods mainly rely on limited domain-specific knowledge when predict...

Predicting Drug-Target Affinity by Learning Protein Knowledge from Biological Networks

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Biochemistry, Bioengineering, Biophysics,
drug-target affinity   variational graph autoencoders   graph convolutional network   protein-protein interaction  

Predicting Drug-Target Affinity Based on Learning Protein Knowledge from Biological Networks Background The prediction of drug-target affinity (DTA) plays a crucial role in drug discovery. Efficient and accurate DTA prediction can significantly reduce the time and economic costs of new drug development. In recent years, the explosive development of...