Hypoxia- and Postirradiation Reoxygenation-Induced HMHA1/ARHGAP45 Expression Contributes to Cancer Cell Invasion in a HIF-Dependent Manner

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
hypoxia   radiation   reoxygenation   cancer cell invasion   HIF-dependent   HMHA1   ARHGAP45  

Contribution of HMHA1/ARHGAP45 Expression Induced by Hypoxia and Post-Radiation Reoxygenation to Cancer Cell Invasion: An HIF-Dependent Mechanism Background and Motivation Prior studies have extensively demonstrated that cancer cells in solid tumors acquire malignant characteristics such as invasiveness and treatment resistance under hypoxic condit...

Genomic Profiling of Small Bowel Adenocarcinoma: A Pooled Analysis from 3 Databases

Medicine, Medical Laboratory Science, Gastroenterology, Oncology, Life Sciences, Biochemistry, Genetics,
small bowel adenocarcinoma   genomic profiling   mutations   prognosis   staging   prognostic factors   biomarkers  

Overview of Genomics in Small Bowel Adenocarcinoma: A Data Integration Analysis Based on Three Major Databases Background and Significance of the Study Small Bowel Adenocarcinoma (SBA) is a rare tumor, but its incidence has increased in recent years, especially in duodenal adenocarcinoma. Approximately 20% of SBA patients have certain susceptibilit...

Oncofetal SNRPE Promotes HCC Tumorigenesis by Regulating FGFR4 Expression through Alternative Splicing

Medicine, Hepatobiliary System, Oncology, Life Sciences, Cell Biology, Biochemistry,
SNRPE   Hepatocellular carcinoma   FGFR4   Alternative splicing   Tumor therapeutic target  

Study on the Key Role of Oncofetal snrpe in the Tumorigenesis and Progression of Hepatocellular Carcinoma Research Background and Purpose Hepatocellular carcinoma (HCC) is the sixth most prevalent cancer worldwide and the third leading cause of cancer-related deaths. However, due to the lack of understanding of key molecular events in tumors, effec...

Tumour Microenvironment-Mediated Drug Resistance in Neuroblastoma

Medicine, Pediatrics, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Neuroblastoma   Drug Resistance   Tumour Microenvironment   TGF-β1   Nuclear Factor-κB   Therapy  

Background Research Background: Both intrinsic and extrinsic factors in the tumor microenvironment (TME) can lead to treatment resistance. This paper reveals that the Transforming Growth Factor (TGF)-β1 produced within the TME increases drug resistance in neuroblastoma (NB) cells. Drug resistance is the main cause of cancer treatment failure, usual...

Plasma Membrane Damage Limits Replicative Lifespan in Yeast and Induces Premature Senescence in Human Fibroblasts

Medicine, Geriatrics, Life Sciences, Cell Biology, Biochemistry, Immunology,
plasma membrane damage   replicative lifespan   premature senescence   yeast   fibroblasts  

Scientific Research Report: Plasma Membrane Damage Limits Yeast Replicative Lifespan and Induces Premature Senescence in Human Fibroblasts Background and Research Motivation Plasma Membrane Damage (PMD) is a phenomenon experienced by all cell types in response to environmental disturbances and spontaneous cellular activities. Previous studies have ...

HLA-A+ Tertiary Lymphoid Structures with Reactivated Tumor-Infiltrating Lymphocytes Are Associated with a Positive Immunotherapy Response in Esophageal Squamous Cell Carcinoma

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
HLA-A+   Tertiary Lymphoid Structures   Esophageal Squamous Cell Carcinoma   Immunotherapy   Tumor-Infiltrating Lymphocytes   Antigen Presenting Machinery   Gene Expression  

In esophageal squamous cell carcinoma (ESCC), immune checkpoint blockade (ICB) therapy has achieved significant clinical benefits. However, the overall response rate to ICB treatment remains low. This study aims to identify biomarkers for ESCC response to ICB therapy and explore their potential clinical relevance. The authors of the paper come from...