Predicting Drug-Target Affinity by Learning Protein Knowledge from Biological Networks

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Biochemistry, Bioengineering, Biophysics,
drug-target affinity   variational graph autoencoders   graph convolutional network   protein-protein interaction  

Predicting Drug-Target Affinity Based on Learning Protein Knowledge from Biological Networks Background The prediction of drug-target affinity (DTA) plays a crucial role in drug discovery. Efficient and accurate DTA prediction can significantly reduce the time and economic costs of new drug development. In recent years, the explosive development of...

Knowledge-Enhanced Graph Topic Transformer for Explainable Biomedical Text Summarization

Information Science, Computer Science, Artificial Intelligence, Medicine, Environmental and Public Health, Medical Laboratory Science, Life Sciences, Biochemistry,
biomedical text summarization   domain knowledge   graph neural network   explainability   pre-trained language models  

Application of Knowledge-Enhanced Graph Topic Transformer in Interpretable Biomedical Text Summarization Research Background Due to the continuous increase in the volume of biomedical literature, the task of automatic biomedical text summarization has become increasingly important. In 2021 alone, 1,767,637 articles were published in the PubMed data...

Single-Subject Cortical Morphological Brain Networks: Phenotypic Associations and Neurobiological Substrates

Medicine, Basic Medical Sciences, Neurology, Medical Imaging, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics, Biophysics,
morphological brain network   structural magnetic resonance imaging   cortical thickness   sex   neurotransmitter  

This paper is a study on the phenotypic associations and neurobiological bases of single-subject morphological brain networks. Combining multimodal and multiscale data, this study reveals the differences in morphological brain networks between genders, their potential as individual-specific markers, and their relationships with gene expression, lay...

Histone 3 Lysine 9 Acetylation-Specific Reprogramming Regulates Esophageal Squamous Cell Carcinoma Progression and Metastasis

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Histone H3   Lysine 9 Acetylation   Esophageal Squamous Cell Carcinoma   Progression   Metastasis   Epigenetic Reprogramming  

The Mechanism of Action of Specific Reprogramming of Histone H3 Lysine 9 Acetylation (H3K9ac) in the Progression and Metastasis of Esophageal Squamous Cell Carcinoma (ESCC) Background Esophageal cancer is one of the most prevalent and invasive malignant tumors globally, causing over 500,000 cancer-related deaths annually, ranking sixth among cancer...

Modification of the Tumor Microenvironment Enhances Immunity with Plasmid Gene Therapy

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Biochemistry, Immunology,
tumor microenvironment   plasmid gene therapy   immunity   MHC-I   PD-L1   antitumor effect   electroporation  

The research team consisting of Guilan Shi, Jody Synowiec, Julie Singh, and Richard Heller published a paper titled “Modification of the tumor microenvironment enhances immunity with plasmid gene therapy” in Cancer Gene Therapy. The background of the study stems from current challenges in the field of tumor immunotherapy, such as tumor cells evadin...

Schwann cell derived pleiotrophin stimulates fibroblast proliferation and excessive collagen deposition in plexiform neurofibroma

Medicine, Medical Laboratory Science, Oral Sciences, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Schwann cells   pleiotrophin   fibroblasts   plexiform neurofibroma   collagen deposition   signaling pathway  

This study explores the interactions between Schwann cells and fibroblasts in neurofibromatosis type 1 (NF1) related plexiform neurofibroma (PNF). The background of the research is based on the high incidence of NF1, which affects about 1 in 3000 newborns worldwide and is associated with a series of unique clinical manifestations. PNF is a common p...