Dysfunctional circadian clock accelerates cancer metastasis by intestinal microbiota triggering accumulation of myeloid-derived suppressor cells

Dysfunctional circadian clock accelerates cancer metastasis by intestinal microbiota triggering accumulation of myeloid-derived suppressor cells

Medicine, Gastroenterology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Microbiology,
circadian rhythm   cancer metastasis   intestinal microbiota   myeloid-derived suppressor cells   tumor microenvironment  

Disruption of Circadian Rhythm Promotes Cancer Metastasis and Myeloid-Derived Suppressor Cell Accumulation Triggered by Intestinal Microbes Academic Background and Research Motivation Cancer metastasis is the leading cause of death for most cancer patients, with colorectal cancer (CRC) drawing significant attention due to its high global incidence ...

Genetic Associations with an Amyotrophic Lateral Sclerosis Reversal Phenotype

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
Amyotrophic Lateral Sclerosis   Reversal Phenotype   Genome-Wide Association Study   Gene Expression   IGFBP7  

Genetic Association Study of ALS Reversal Phenotype Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the death of upper and lower motor neurons, progressive weakness, and eventual respiratory failure. However, individual ALS patients have exhibited unusual clinical reversal phenomena, where symptoms signific...

Pathologic Substrates of Structural Brain Network Resilience and Topology in Parkinson Disease Decedents

Medicine, Basic Medical Sciences, Neurology, Medical Imaging, Life Sciences, Cell Biology, Biochemistry,
Parkinson's disease   brain network   α-synuclein   diffusion-weighted imaging   network resilience  

Scientific Paper News Report: Pathological Basis and Topological Properties of Structural Brain Networks in Parkinson’s Disease Patients Background and Research Objectives In Parkinson’s disease (PD), α-synuclein spreads between connected brain regions, leading to neuronal loss and brain network disruption. Using diffusion-weighted imaging (DWI), t...

A Comprehensive Overview of NF1 Mutations in Iranian Patients

Medicine, Medical Laboratory Science, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
NF1   mutation   Iranian   whole-exome sequencing   genetic counseling  

Comprehensive Overview of Mutations in Neurofibromatosis Type 1 Among Iranian Patients Neurofibromatosis type 1 (NF1) is a hereditary disease caused by mutations in the NF1 gene, characterized by almost complete penetrance and high phenotypic variability. This study aims to identify NF1 mutations in Iranian patients using whole-genome exome sequenc...

Astaxanthin Rescues Memory Impairments in Rats with Vascular Dementia by Protecting Against Neuronal Death in the Hippocampus

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
vascular dementia   astaxanthin   Alzheimer’s disease   neurodegenerative diseases   neuronal apoptosis  

Astaxanthin Protects Hippocampal Neurons Against Memory Impairment Caused by Vascular Dementia in Rats Background Introduction Vascular Dementia (VAD) is a progressive cognitive disorder caused by cerebrovascular disease leading to cognitive decline. Current research shows that chronic cerebral hypoperfusion (CCH) and insufficient blood supply are ...

Evaluation of Neuroprotective Effect of Gut Microbe in Parkinson's Disease: An In Silico and In Vivo Approach

Medicine, Neurology, Life Sciences, Biochemistry, Immunology, Microbiology,
α-synuclein   gut microbes   metabolites   protein-protein interaction   therapeutic agent   parkinsonian mice model  

Study on the Protective Effects of Medicinal Microorganisms on Parkinson’s Disease Background Introduction Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterized by the death of dopaminergic neurons in the substantia nigra region of the brain. The aggregation of α-synuclein is a crucial factor in the pathogenesis of Park...