Reactive Oxygen Species Regulation by NCF1 Governs Ferroptosis Susceptibility of Kupffer Cells to MASH

Medicine, Hepatobiliary System, Life Sciences, Cell Biology, Biochemistry, Immunology,
Reactive Oxygen Species   NCF1   Kupffer Cells   Iron Homeostasis   Ferroptosis   MASH   Lipid Peroxidation  

NCF1 Regulates Reactive Oxygen Species Vulnerability to Ferroptosis in Kupffer Cells and Its Impact on MASH Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), has a global prevalence of up to 25.2% and is a leading cause of chronic liver disease in adults and c...

Short-Term Cold Exposure Induces Persistent Epigenomic Memory in Brown Fat

Medicine, Basic Medical Sciences, Urology, Endocrinology, Life Sciences, Cell Biology, Biochemistry,
short-term cold exposure   epigenomic memory   brown fat   HDAC3   C/EBPβ   adaptive thermogenesis  

Short-term Cold Exposure Induces Persistent Epigenomic Memory in Brown Adipose Tissue Background Brown Adipose Tissue (BAT) is the primary non-shivering thermogenic organ in mammals that dissipates chemical energy as heat under cold stimuli. BAT is characterized by a high density of mitochondria containing Uncoupling Protein 1 (UCP1), which generat...

Nicotinamide Metabolism Face-off Between Macrophages and Fibroblasts Manipulates the Microenvironment in Gastric Cancer

Medicine, Gastroenterology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Nicotinamide Metabolism   Macrophages   Fibroblasts   Gastric Cancer   Tumor Microenvironment   Immunotherapy   Extracellular Vesicles  

Macroscopic and Microscopic Mechanisms of Nicotinamide Metabolism Antagonism: Manipulation of the Gastric Cancer Microenvironment Background Introduction Gastric cancer (GC) is a type of cancer characterized by a unique and heterogeneous tumor microenvironment (TME). Despite advances in immune checkpoint blockade (ICB) therapy for gastric cancer, n...

A Microbial Metabolite Inhibits the HIF-2α-Ceramide Pathway to Mediate the Beneficial Effects of Time-Restricted Feeding on MASH

Medicine, Hepatobiliary System, Basic Medical Sciences, Life Sciences, Biochemistry, Microbiology,
Microbial Metabolite   Time-Restricted Feeding   HIF-2α   Ceramide   MASH   MASLD   Ruminococcus Torques  

A Microbial Metabolite Mediates the Beneficial Effects of Time-Restricted Feeding on MASH by Inhibiting the HIF-2A-Ceramide Pathway Introduction Background: Metabolic Dysfunction-Associated Steatotic Liver Disease/Metabolic Dysfunction-Associated Steatohepatitis (MASLD/MASH) is a major health problem affecting a quarter of the global population. MA...

Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis

Medicine, Respiratory System, Life Sciences, Cell Biology, Biochemistry, Immunology,
dopaminylation   endothelial cells   TPI1   ferroptosis   lung regeneration   fibrosis   metabolism  

Dopamine Modification of TPI1 Inhibits Ferroptosis Signaling in Vascular Endothelial Cells, Promoting Lung Regeneration and Inhibiting Fibrosis Background The regenerative capability of the lung enables it to restore its original functional tissue after injury. However, if this regenerative process is disrupted, it often leads to maladaptive repair...

Electron Transport Chain Inhibition Increases Cellular Dependence on Purine Transport and Salvage

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry,
electron transport chain   purine metabolism   cell growth   metabolic reprogramming   non-small cell lung cancer  

Inhibition of the electron transport chain increases cell dependence on purine transport and salvage Research Background The electron transport chain (ETC) is a key mechanism in mitochondria responsible for energy generation, playing an important role in maintaining cellular homeostasis and growth. However, it remains unclear how cells adjust their...