Research Background This study explores the role of the cancer-related transcription factor c-myc in penumbra neurons following ischemic stroke. Although the role of c-myc in cell death and survival has been recognized, research on its post-translational modifications, especially acetylation, in ischemic models remains insufficient. Investigating t...

Preliminary Research Report on the Relationship between CYP46A1 Polymorphism and Suicide Risk Research Background Suicide, defined as the intentional act of ending one’s own life, is a major global public health issue. The incidence of suicide is higher among individuals with Major Depressive Disorder (MDD). However, the role of cholesterol in suic...

Scientific Research Report: Drug Treatment Alleviates Retinal Ganglion Cell Death in Normal Tension Glaucoma Mouse Model by Inhibiting Collapsin Response Mediator Protein 2 Phosphorylation Background Normal Tension Glaucoma (NTG) is a progressive neurodegenerative disease in the glaucoma family. Typically, glaucoma is associated with elevated intra...

Long-term Effects of CD8+ T Cell Subsets in Neuroinflammation After Ischemic Stroke Background Ischemic stroke is a leading cause of death and disability. After stroke, neuroinflammation is rapidly induced, activating various cells such as mast cells, astrocytes, microglia, and vascular endothelial cells. These reactive cells then express various i...

Study on the Improvement of Cognitive Function in ICV-STZ-Induced Alzheimer’s Disease Mouse Model by Lycium Barbarum Polysaccharides Research Background Alzheimer’s disease (AD) is the most common neurodegenerative disease of the central nervous system, characterized by progressive cognitive impairment, memory loss, personality changes, and emotion...

Effects of Clemizole on Parkinson’s Disease Pathology Induced by α-Synuclein Fibril Formation Background Introduction Parkinson’s Disease (PD) is a typical neurodegenerative disease, mainly associated with mitochondrial dysfunction and oxidative stress. However, current therapeutic approaches targeting these pathological events have not successfull...