A Novel Method to Study CSF Flow and BOLD Coupling Using Real-Time Phase Contrast Interleaved with Cortical BOLD MRI

Medicine, Neurology, Medical Imaging, Life Sciences, Biophysics,
CSF flow   real-time phase contrast   BOLD   glymphatic system   brain clearance   BOLD-CSF coupling  

New Method for Studying the Coupling Between Cerebrospinal Fluid Flow and Cortical BOLD Signals Academic Background In recent years, the role of cerebrospinal fluid (CSF) in brain waste clearance has garnered significant attention. Traditionally, CSF was thought to primarily serve as a cushion and provide immune surveillance. However, growing evide...

Development and Application of an Automated In Vitro Model for Hydrocephalus Research

Medicine, Neurology, Life Sciences, Bioengineering,
hydrocephalus   in vitro modeling   cerebrospinal fluid flow pattern   CSF dynamics   microfluidic   pump   bioreactor  

Application of Automated In Vitro Models in Hydrocephalus Research Background Introduction Hydrocephalus is a neurological condition caused by the accumulation of cerebrospinal fluid (CSF) in the brain’s ventricles. If left untreated, it can lead to severe complications and permanent brain damage. It is estimated that 1 in every 500 newborns is bor...

Numerical Study of the Effects of Minor Structures and Mean Velocity Fields in the Cerebrospinal Fluid Flow

Physics, Fluid Physics, Engineering, Mechanical Engineering, Medicine, Neurology, Life Sciences, Bioengineering,
cerebrospinal fluid   intrathecal injection   computational fluid dynamics   lagrangian velocity   spinal subarachnoid space   fluid transport   geometric variability  

Study on Cerebrospinal Fluid Flow Dynamics and Its Application in Drug Delivery Background Introduction Cerebrospinal fluid (CSF) plays a crucial role in the human spinal canal, responsible for transporting dissolved nutrients and waste products. Due to its pulsatile nature, CSF flow is influenced by cardiac and respiratory cycles. In recent years,...

Brain Endothelial Permeability, Transport, and Flow Assessed Over 10 Orders of Magnitude Using the In Situ Brain Perfusion Technique

Medicine, Neurology, Life Sciences,
blood brain barrier   enhanced dissociation   pharmaceutical screening   diazepam   albumin   alpha-1 acid glycoprotein   neurovascular unit  

Assessment of Brain Endothelial Permeability, Transport, and Flow Background Introduction The blood-brain barrier (BBB) is a critical barrier that protects the brain from harmful substances while also serving as a key obstacle for drug delivery to the brain. The permeability and transport properties of the BBB directly influence the distribution of...

Role of the Transcription Factor Nrf2 in Maintaining the Integrity of the Blood-Brain Barrier

Medicine, Neurology, Life Sciences,
Nrf2   blood-brain barrier   inflammation   oxidative stress   neurological disorders   tight junction   phytochemicals  

The Role of Nrf2 in Maintaining the Integrity of the Blood-Brain Barrier Academic Background The blood-brain barrier (BBB) is a crucial barrier between the central nervous system (CNS) and the peripheral blood circulation, composed of endothelial cells, pericytes, smooth muscle cells, astrocytes, and neurons. The primary function of the BBB is to s...