Study on the Regulatory Mechanism of tsRNA-Gln-i-0095 in Retinal Ischemia-Reperfusion Injury Academic Background Retinal ischemia-reperfusion (I/R) injury is a critical pathological mechanism in various ocular diseases, including glaucoma, central retinal vein occlusion, and retinopathy of prematurity. I/R injury leads to the death of retinal gangl...

The Critical Role of Calcium in Skeletal Muscle Function and Its Interaction with Mitochondria and the Endoplasmic Reticulum Academic Background Calcium ions (Ca²⁺) are crucial intracellular signaling molecules, particularly in the excitation-contraction coupling (ECC) of skeletal muscle. The contraction of skeletal muscle relies on the release and...

POLDIP2 Regulates Cerebral Vascular Permeability by Modulating ROS-Mediated ZO-1 Phosphorylation and Localization Background The blood-brain barrier (BBB) is a critical component of the central nervous system (CNS), composed of brain endothelial cells, astrocytes, pericytes, and neurons. Brain endothelial cells form a continuous physical barrier th...

N88S Seipin-related Seipinopathy is a Lipidopathy Associated with Loss of Iron Homeostasis Academic Background Seipin is a protein encoded by the human BSCL2 gene and the yeast SEI1 gene, forming an endoplasmic reticulum (ER)-bound homo-oligomer. This oligomer plays a crucial role in targeting ER-lipid droplet (LD) contact sites, facilitating the d...

PRDX5 and PRDX6 in Oxidative Stress Response During Cryopreservation of Bull Sperm Academic Background Cryopreservation is a critical step in animal breeding and assisted reproductive technologies, particularly in the preservation of bull sperm. However, oxidative stress generated during cryopreservation significantly reduces sperm quality, leading...