Report on the Study of Diatom Phytochromes Integrating Underwater Light Spectrum to Sense Depth Academic Background The distribution of light in marine ecosystems profoundly influences aquatic life. Light not only attenuates with depth but also undergoes significant spectral changes. However, research on how phytoplankton perceive these light chang...

The Conformational Space of RNase P RNA in Solution Academic Background The conformational diversity of RNA plays a crucial role in biology, particularly in processes such as RNA splicing, packaging, cellular transcriptional activation, and responses to environmental stimuli. However, traditional biophysical techniques have been unable to directly ...

Spatial Transcriptomic Clocks Reveal Cell Proximity Effects in Brain Aging Academic Background With aging, cognitive function declines, and the risk of neurodegenerative diseases significantly increases. Brain aging is a complex process accompanied by numerous cellular changes. However, how aging cells affect neighboring cells and how this contribu...

Academic Background RNA (ribonucleic acid) is a crucial molecule in living organisms, involved in various biological processes such as gene expression, regulation, and catalysis. Although a significant portion of the human genome is transcribed into RNA, the structural study of RNA molecules remains a major challenge. RNA molecules typically exhibi...

Academic Background and Problem Statement In cancer research, gene amplification is a common form of mutation, particularly in the activation of oncogenes. However, despite the widely recognized importance of gene amplification in cancer, precisely modeling these amplifications in primary cells and model organisms remains a challenge. Specifically,...